恶性腮腺肿瘤中基质与瘤周 TIL（肿瘤浸润淋巴细胞）的探索性分析：与临床病理因素及生存的关联

The tumour immune microenvironment may influence prognosis in many cancers, but its significance in malignant parotid gland tumours is not well defined. AIMS/OBJECTIVES: To evaluate whether stromal and peritumoural tumour-infiltrating lymphocyte (TIL) density is associated with clinicopathological features and overall survival in malignant parotid gland tumours. MATERIAL AND METHODS: Thirty patients who underwent surgery for malignant parotid gland tumours (2013-2024) were retrospectively analysed. Stromal and peritumoural TIL densities were assessed on haematoxylin-eosin-stained sections and recorded as percentages. For exploratory survival analysis, TIL density was grouped as low-intermediate (0-40%) or high (50-90%). Overall survival was evaluated using Kaplan-Meier analysis and the log-rank test.

Mean age was 54.9 16.1 years. Higher peritumoural TIL density was associated with longer overall survival (log-rank p = 0.045). No significant relationships were found between TIL density and other clinicopathological variables. CONCLUSIONS AND SIGNIFICANCE: These exploratory findings suggest that increased peritumoural TIL density may indicate better survival in malignant parotid gland tumours. TIL assessment could provide prognostic information, but larger prospective studies are needed.