CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
靶向肿瘤相关巨噬细胞中 toll 样受体通路的治疗策略
英文原题：Therapeutic targeting of toll-like receptor pathways in tumor-associated macrophages.
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Therapeutic targeting of toll-like receptor pathways in tumor-associated macrophages.
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中文摘要
肿瘤相关巨噬细胞（TAMs）是肿瘤微环境（TME）的核心调控者，塑造免疫抑制、肿瘤进展和治疗耐药。Toll样受体（TLRs）协调固有免疫激活，是重编程TAMs向抗肿瘤状态转化的一个有吸引力的轴心。然而，TLR信号的情境依赖性，加上TME中的代谢和耐受性限制，构成了重大的转化障碍。尽管如此，包括嵌合抗原受体巨噬细胞（CAR-M）和抗体-TLR激动剂偶联物在内的最新进展，为以更高精度和安全性利用TLR信号提供了新途径。本综述总结了巨噬细胞中TLR信号的分子基础，剖析了肿瘤内TLR激活的双向后果，评估了当前的治疗平台，并勾勒了指导基于TLR的TAM调控临床开发的转化路线图。
展开英文摘要原文
Tumor-associated macrophages (TAMs) are central regulators of the tumor microenvironment (TME), shaping immune suppression, tumor progression, and therapeutic resistance. Toll-like receptors (TLRs) orchestrate innate immune activation and represent a compelling axis for reprogramming TAMs toward antitumor states.
However, the context-dependent nature of TLR signaling, combined with metabolic and tolerogenic constraints in the TME, presents substantial translational barriers. Nevertheless, recent advances including chimeric antigen receptor macrophage (CAR-M) and antibody-TLR agonist conjugates offer new pathways to harness TLR signaling with improved precision and safety.
This review summarizes the molecular foundations of TLR signaling in macrophages, dissects the bidirectional consequences of TLR activation within tumors, evaluates current therapeutic platforms, and outlines a translational roadmap to guide the clinical development of TLR-based TAM modulation.
论文信息
- 作者
- Wang L、Li Y、He Z、Chen Z、Zhang W、Wu C、Xue L、Cao X
- 第一作者单位
- Shanghai Frontiers Science Center for Drug Target Identification and Delivery, and the Engineering Research Center of Cell and Therapeutic Antibody of the Ministry of Education, School of Pharmaceutical Sciences, State Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, China.China
- 通讯作者单位
- Shanghai Frontiers Science Center for Drug Target Identification and Delivery, and the Engineering Research Center of Cell and Therapeutic Antibody of the Ministry of Education, School of Pharmaceutical Sciences, State Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, China. Electronic address: xcao@sjtu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Cytokine & growth factor reviews2026 Apr
- 原文标识
- PubMed 41719637 · DOI 10.1016/j.cytogfr.2026.02.001