CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
整合药物递送与抗体制造的工程化细菌工厂，用于激活 STING 信号通路介导的肿瘤免疫治疗
英文原题：Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy.
查看英文原题
Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy.
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中文摘要
巨噬细胞在细胞免疫治疗中展现出巨大应用潜力，但受到免疫检查点（ICBs）的限制。免疫检查点抑制剂（ICIs）能够有效阻断免疫逃逸通路并缓解肿瘤微环境（TME）中的免疫抑制。在此，我们构建了缺氧响应细菌（HRB），其可在TME的缺氧条件下特异性表达CD47抗体（aCD47），从而在肿瘤部位原位合成ICIs。此外，本研究进一步制备了响应性脂质体用于包封STING激动剂cGAMP，并通过共价连接修饰于HRB表面，形成复合材料HRB@LC。该复合系统能够协同阻断CD47-SIRPα介导的免疫逃逸并激活STING信号通路，从而增强全身抗肿瘤免疫应答并显著提高免疫治疗疗效。
展开英文摘要原文
Macrophages show great potential for application in cellular immunotherapy, but are limited by immune checkpoints (ICBs). Immune checkpoint inhibitors (ICIs) can effectively block immune escape pathways and alleviate immune suppression in the tumor microenvironment (TME).
Here, we constructed hypoxia response bacteria (HRB) that specifically expressed CD47 antibody (aCD47) under hypoxic conditions in the TME, enabling the in situ synthesis of ICIs at the tumor site.
In addition, this study further prepared responsive liposomes for encapsulating the STING agonist cGAMP and modified them by covalent attachment to the HRB surface to form the composite material HRB@LC. This composite system can synergistically block CD47-SIRPα-mediated immune escape and activate the STING signal pathway, thereby enhancing systemic antitumor immune responses and significantly improving the efficacy of immunotherapy.
论文信息
- 作者
- Dong PS、Yao T、Li Y、Yan ZH、Xie XT、Zou JH、Cheng K、Fan JX
- 第一作者单位
- Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.China
- 通讯作者单位
- Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine, Zhejiang Provincial People's Hospital Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China.China
- 期刊
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026 May
- 原文标识
- PubMed 41709777 · DOI 10.1002/advs.202518172
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