白细胞介素-15 与固有效应细胞作为异基因造血干细胞移植结局的预测因素

In this prospective study, we investigated associations between IL-15 and IL-7, NK cells and T cells, including activated subtypes, and clinical outcomes. We included 105 patients undergoing allogeneic HCT at a single-center institution. IL-15, IL-7, and extended T and NK cell phenotyping were measured longitudinally at fixed time points following HCT.

We found high IL-15 concentrations early post-transplant to be significantly associated with reduced overall survival, reduced relapse-free survival, and excess acute GVHD. Furthermore, IL-15 showed significant inverse correlations with NK cells and T cells, including activated subtypes early after HCT, and with conventional T cells at later time points. IL-7 was significantly inversely correlated not only with conventional T cells but also with T cells early after HCT. DISCUSSION: These findings may suggest that early immune reconstitution of NK cells and T cells is influenced by the bioavailability of IL-15 after HCT and that IL-15 could have a mechanistic effect in the activity of these innate effector cells. NK cells and T cells are currently being investigated in several promising treatment settings, and IL-15 here may offer a potential benefit.