γδ T 细胞调节小细胞肺癌中的抗肿瘤免疫
γδ T cells modulate anti-tumor immunity in small cell lung cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
遵循“DOTs”：Vδ1+ γδ T 细胞作为癌症免疫疗法的效应细胞
英文原题：Follow the "DOTs": Vδ1+ γδ T cells as effectors of cancer immunotherapy.
查看英文原题
Follow the "DOTs": Vδ1+ γδ T cells as effectors of cancer immunotherapy.
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中文摘要
癌症免疫治疗主要依赖常规T细胞在有限类型的肿瘤中取得成功。通过免疫干预有效治疗更多种类癌症的一个有前景的途径是动员其他抗肿瘤效应细胞，如γδ T细胞。其中，Vδ1+亚群通常在外周组织和肿瘤内占主导地位，通常与良好预后相关。在本期Found in Translation中，我们讨论如何利用Vδ1+ γδ T细胞的生物学特性进行癌症免疫治疗，特别关注delta one T (DOT)细胞方法。
展开英文摘要原文
Cancer immunotherapy has mostly relied on conventional T cells to achieve success in a limited set of tumor types. A promising avenue to expand the repertoire of cancers effectively treated through immune intervention is to mobilize other anti-tumor effectors, such as γδ T cells.
Among these, the Vδ1+ subset commonly predominates within peripheral tissues and within tumors, typically associating with good prognosis. In this Found in Translation, we discuss how to leverage the biological properties of Vδ1+ γδ T cells for cancer immunotherapy, with special focus on the delta one T (DOT) cell approach.
论文信息
- 作者
- Silva-Santos B、Mensurado S、Blanco-Domínguez R、Hayday AC
- 第一作者单位
- Gulbenkian Institute for Molecular Medicine , Lisbon, Portugal.Portugal
- 通讯作者单位
- King's College London , London, UK.United Kingdom
- 文献类型
- 综述
- 期刊
- The Journal of experimental medicine2026 Mar 2
- 原文标识
- PubMed 41670625 · DOI 10.1084/jem.20252289
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