CELL INTELLIGENCE · 肿瘤细胞治疗研究

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STAb-T 细胞的生成与功能评估

英文原题：Generation and functional evaluation of STAb-T cells.

查看英文原题

Generation and functional evaluation of STAb-T cells.

PubMed 2025/04/09（内容时间） Methods Cell Biol

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技术：双特异性抗体血液系统恶性肿瘤地区：欧洲
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中文摘要

STAb-T疗法是一种新兴的癌症免疫治疗策略，结合了过继性细胞疗法和双特异性抗体的优势。STAb（分泌T细胞衔接器双特异性抗体）T细胞是经过基因工程改造的T淋巴细胞，能够分泌双特异性T细胞衔接器（TCE），将T细胞募集到肿瘤细胞处进行靶向杀伤。STAb-T细胞的过继转移已在临床前模型中展现出强效抗肿瘤活性，即将在人类患者中开展评估。在此，我们提供全面的指南，涵盖STAb-T细胞的制备及其在体外和血液恶性肿瘤相关体内模型中的功能与疗效评估。

展开英文摘要原文

STAb-T therapy is an emerging cancer immunotherapy strategy that combines the advantages of adoptive cell therapies and bispecific antibodies. STAb (Secreting T cell engager bispecific Antibodies) T cells are T lymphocytes genetically engineered to secrete bispecific T cell engagers (TCEs) that recruit T cells to target and destroy tumor cells. Adoptive transfer of STAb-T cells has demonstrated potent anti-tumor activity in preclinical models and evaluation in human patients is forthcoming.

Here, we provide comprehensive guidelines for generating STAb-T cells and assessing their functionality and efficacy in vitro and in relevant in vivo models of hematological malignancies.

论文信息

作者
Jiménez-Reinoso A、Blanco B、Álvarez-Vallina L
第一作者单位
Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Electronic address: anjimenez@ext.cnio.es.Spain
通讯作者单位
Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Electronic address: lalvarezv@ext.cnio.es.Spain
期刊
Methods in cell biology2026
原文标识
PubMed 41620271　·　DOI 10.1016/bs.mcb.2025.03.010

在 PubMed 查看 → 出版商原文（DOI） 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →