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近十年来肌苷普拉诺贝的研究——从一种“老”治疗药物到疫苗研究,包括抗癌疫苗

英文原题:The last ten years with inosine pranobex - from an "old" therapeutic agent to vaccine research, including anti-cancer vaccines.

查看英文原题

The last ten years with inosine pranobex - from an "old" therapeutic agent to vaccine research, including anti-cancer vaccines.

PubMed 2025/01/01(内容时间) Cas Lek Cesk

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中文摘要

肌苷普拉诺贝(IP),也称为肌苷普拉诺贝地美普醇,是一种免疫调节药物,已有五十多年的历史。它于20世纪70年代首次问世,此后已在全球50多个国家获得许可。它最初被认为是治疗AIDS的潜在药物,在发现HIV病毒时曾寄予厚望。然而,在最初的兴趣之后,其在该领域的应用逐渐减少,并且在很长一段时间内,IP不再在专业文献或临床实践中被显著讨论。直到过去十年才重新引起兴趣,当时IP开始在与急性呼吸道感染、由人乳头瘤病毒(HPV)引起的疾病以及其他病毒性疾病(包括COVID-19)的治疗相关方面重新出现。它也开始被用作口蹄疫疫苗的佐剂,并且开始了基于IP的抗肿瘤疫苗的研究。

展开英文摘要原文

Inosine pranobex (IP), also known as inosine pranobex dimepranol, is an immunomodulatory drug with a history spanning more than fifty years. It was first introduced in the 1970s and has since been licensed in more than 50 countries around the world. It was originally considered a potential drug for AIDS, which raised high hopes at the time of the discovery of the HIV virus.

However, after initial interest, its use in this area declined, and for a long time, IP was no longer discussed significantly in professional literature or clinical practice. Renewed interest came only in the last decade, when IP began to reappear in connection with the treatment of acute respiratory infections, diseases caused by human papillomavirus (HPV), and other viral diseases, including COVID-19. It also began to be used as an adjuvant in the foot-and-mouth disease vaccine, and research began on an IP-based anti-tumor vaccine.

论文信息

作者
Beran J、Slíva J
文献类型
综述
期刊
Casopis lekaru ceskych2025
原文标识
PubMed 41615790