程序性死亡配体 1 (PD-L1) 和 TIL（肿瘤浸润淋巴细胞）(TILs) 在声门型喉癌中的预后意义

For this study, 40 patients who underwent complete resection of the glottic laryngeal tumor as primary treatment were selected. PD-L1 and TIL expression levels were determined by immunohistochemistry.

Disease-free survival (DFS) was statistically significantly longer in patients with the combined positive score (CPS). CPS 1 than those with CPS <1. The concentration of TILs in tumor specimens was not significantly related to gender, age, T status, N status, tumor, node, metastasis (TNM) stage, pathological grade, or locoregional recurrence. Multivariate Cox regression analysis showed that low CPS and positive nodal status are statistically significant and independent predictors of malignancy recurrence.

The findings of our study suggest that PD-L1 could be a valuable indicator for predicting recurrence and reduced survival following definitive therapy. Consequently, further comprehensive studies involving larger groups of patients are imperative to ascertain the predictive significance of PD-L1 and TIL as biomarkers in LC.