不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
伪装入侵者：结外 NK/T 细胞淋巴瘤模拟眶隔前蜂窝织炎
英文原题：A Masked Intruder: Extranodal Natural Killer/T-Cell Lymphoma Mimicking Preseptal Cellulitis.
查看英文原题
A Masked Intruder: Extranodal Natural Killer/T-Cell Lymphoma Mimicking Preseptal Cellulitis.
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中文摘要
结外自然杀伤/T细胞淋巴瘤是一种罕见的、侵袭性的、与Epstein-Barr病毒相关的恶性肿瘤。我们报告了一例不寻常的病例，患者为一名40多岁的女性，表现为进行性左侧眶周肿胀、发红和疼痛，最初按难治性眶隔前蜂窝织炎治疗。尽管给予了积极的抗生素治疗，症状仍加重。影像学显示累及左侧眼眶的炎性条索影和蜂窝织炎性强化。活检揭示了原发性眼眶结外自然杀伤/T细胞淋巴瘤（鼻型）的诊断，且无鼻窦鼻腔受累，这极为罕见。本病例强调，对于抗生素治疗无反应的眶隔前蜂窝织炎患者，需要考虑其他非感染性诊断。
展开英文摘要原文
Extranodal natural killer/T-cell lymphoma is a rare, aggressive, Epstein-Barr virus-associated malignancy.
We reported an unusual case of a woman in her middle 40s presenting with progressive left-sided periorbital swelling, redness, and pain, initially treated as a refractory preseptal cellulitis. Despite aggressive antibiotic therapy, symptoms worsened. Imaging showed inflammatory stranding and phlegmonous enhancement involving the left orbit.
A biopsy revealed the diagnosis of primary orbital extranodal natural killer/T-cell lymphoma (nasal type) without sinonasal involvement, which is extremely uncommon. This case emphasized the need to consider other noninfectious diagnoses in patients with preseptal cellulitis unresponsive to antibiotics.
论文信息
- 作者
- Fuentes SA、Griepentrog GJ、King RL、Bennani NN、Chesdachai S
- 第一作者单位
- Department of Medicine, Mayo Clinic, Rochester, MN.United States
- 通讯作者单位
- Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, MN.United States
- 文献类型
- 病例报告
- 期刊
- Mayo Clinic proceedings. Innovations, quality & outcomes2026 Feb
- 原文标识
- PubMed 41551633 · DOI 10.1016/j.mayocpiqo.2025.100689
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