肿瘤细胞治疗研究
英文原题：Targeting γδ T cells for immunotherapies against colorectal cancer.
Targeting γδ T cells for immunotherapies against colorectal cancer.
免疫治疗的进步面临重大挑战，包括将其益处扩展至越来越多的患者，以及提高其在不同肿瘤类型中的疗效。
免疫治疗的进展面临重大挑战，包括将其获益扩展至越来越多的患者，以及提高其在不同肿瘤类型中的疗效。在此背景下，γδ T 细胞因其独特的生物学特征而成为特别有前景的候选者，这些特征包括 MHC 非依赖性激活、强大的细胞毒性以及桥接固有免疫和适应性免疫的能力。近年来，先进的单细胞技术使得在肿瘤微环境（TME）中对 γδ T 细胞进行详细表征成为可能，并突出了其异质性、激活机制以及对免疫检查点阻断（ICB）的应答。本综述全面总结了在结直肠癌（CRC）中理解 γδ T 细胞的最新进展，特别强调其在原发肿瘤和转移性疾病中的预后和治疗相关性。
The advancement of immunotherapy faces significant challenges, including extending its benefits to a growing number of patients and enhancing its efficacy across different tumor types. In this context, γδ T cells emerge as particularly promising candidates owing to their distinctive biological features such as MHC-independent activation, potent cytotoxicity, and capacity to bridge innate and adaptive immunity. Recently, advanced single-cell techniques have allowed detailed γδ T cell characterization in the tumor microenvironment (TME) and have emphasized their heterogeneity, mechanisms of activation, and response to immune checkpoint blockade (ICB). This review provides a comprehensive summary of recent advances in understanding γδ T cells in colorectal cancer (CRC), with a particular emphasis on their prognostic and therapeutic relevance in both primary tumors and metastatic disease.
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