塞替派与白消安联合环磷酰胺预处理方案加维持治疗改善复发/难治性血液恶性肿瘤患者异基因移植后的无病生存期

Conditioning regimens are critical for patients with relapsed/refractory (R/R) malignant hematologic diseases. Thiotepa, an alkylating agent with excellent cytotoxicity and blood brain barrier permeability, has been widely used in conditioning regimens for lymphoma and has recently been used in patients with acute leukemia with central nervous system involvement. The aim of this retrospective study was to observe the efficacy and safety of a conditioning regimen comprising thiotepa, busulfan, and cyclophosphamide (TBC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with R/R hematologic diseases. Between July 2022 and December 2023, 27 patients were selected. With a median follow-up of 609 (243-954) days, the 1-year and estimated 2-year overall survival (OS) rates were 85.

2% 6. 8% and 76. 5% 8. 5%, respectively. The 1-year and estimated 2-year disease-free survival (DFS) rates were 81. 5% 7. 5% and 62. 8% 12. 2%, respectively. Six patients experienced relapse, and the 1-year and estimated 2-year cumulative incidence of relapse (CIR) rates were 14. 8% 6. 8% and 31. 0% 12. 6%, respectively. Two patients died from graft-versus-host disease (GVHD) or infection.

The 1-year and estimated 2-year nonrelapse mortality (NRM) rates were 4. 2% 4. 1% and 8. 5% 5. 8%, respectively. 14 (51. 9%) patients received maintenance therapy after allo-HSCT. Regimen-related toxicities were mostly well tolerated. Multivariate analysis revealed that failure to achieve first complete remission (CR1) before HSCT and previous treatment with CAR-T cell were predictors of poor DFS.

This study suggests that the TBC conditioning regimen may be a promising option for patients with R/R hematologic diseases undergoing allo-HSCT.