CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：CRISPR's impact on cancer: From fundamental models to clinical solutions.
CRISPR's impact on cancer: From fundamental models to clinical solutions.
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CRISPR是一种可编程的基因组编辑方法，已彻底改变基因组工程并推动癌症研究进展。CRISPR的各种工程化迭代，包括碱基编辑和先导编辑，促进了更精确、更灵活的基因组操作，为理解和对抗癌症开辟了新前沿。本综述强调CRISPR在癌症生物学中的重要影响，从其能够在细胞和动物模型中准确重建体细胞突变的能力，到其在开发精确诊断工具中的应用。我们还探讨了癌症治疗的进展，特别是通过体外工程化改造强效嵌合抗原受体（CAR）T细胞，使其能够在限制性肿瘤微环境中有效发挥作用。最后，我们考虑了CRISPR-Cas系统现有的局限性，并概述了未来方向，这些方向可能进一步增强这一强大技术在抗癌中的应用。
CRISPR is a programmable genome editing method that has transformed genome engineering and advanced cancer research. Various engineering iterations of CRISPR, including base and prime editing, facilitate more accurate and adaptable genomic manipulations, opening new frontiers in understanding and combating cancer. This review emphasizes CRISPR's significant influence in cancer biology, from its ability to accurately recreate somatic mutations in cellular and animal models to its application in developing precise diagnostic tools.
We also examine advancements in cancer therapies, particularly through the ex vivo engineering of robust chimeric antigen receptor (CAR) T cells that perform effectively in restrictive tumor microenvironments. Lastly, we consider the existing limitations of CRISPR-Cas systems and outline future directions that could further enhance the application of this powerful technology against cancer.
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