CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Tumor Microenvironment: Recent Advances in Immunotherapies of Pancreatic Cancer.
Tumor Microenvironment: Recent Advances in Immunotherapies of Pancreatic Cancer.
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胰腺癌（PC）的进展受免疫系统的显著影响。在美国，PC是癌症相关死亡的第三大原因。PC的高致死率归因于其免疫学优势，这得益于免疫抑制微环境、低突变负荷和极少的T细胞浸润。尽管免疫疗法，如检查点阻断或基因工程T细胞，尚未显示出可行性，但越来越多的证据表明，传统疗法与各种方法的创新组合可能为PC治疗带来有效的免疫疗法。本综述聚焦于肿瘤微环境的重要性以及免疫疗法在PC中的前景。
The progression of pancreatic cancer (PC) is significantly influenced by the immune system. In the United States, PC is the third leading cause of cancer-related mortality. The high lethality of PC is attributed to its immunological advantage, which is facilitated by an immunosuppressive microenvironment, a low mutational burden, and minimal T-cell infiltration.
Although immunotherapies, such as checkpoint blockades or genetically engineered T cells, have not yet demonstrated viability, there is a growing body of evidence suggesting that innovative combinations of conventional therapies and various procedures may lead to effective immunotherapy in the treatment of PC. This review focuses on the importance of the tumor microenvironment and the promising role of immunotherapies in PC.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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