CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
高 VCP/p97 表达与口咽鳞状细胞癌中低 PD-L1 TPS 相关
英文原题：High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma.
查看英文原题
High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma.
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研究概要
VCP/p97 在 OPSCC 中频繁过表达。高 VCP/p97 表达与低 PD-L1 TPS 和减少的 iTILs 显著相关，这可能表明 VCP/p97 抑制剂治疗可以增强 PD-1 检查点抑制剂治疗在 OPSCC 中的疗效。
研究思路结论见上方概要
VCP/p97抑制已知可上调PD-L1。本研究探讨了OPSCC中PD-L1与VCP/p97表达的相关性，以及VCP/p97在OPSCC中的表达及预后意义。
该研究回顾性纳入56例OPSCC患者。采用免疫组化染色检测VCP/p97和PD-L1表达。测定VCP/p97的染色强度以及PD-L1 TPS和CPS。通过针对p16的免疫组化染色和HPV PCR评估HPV状态。此外，还评估了iTILs。
67.9%的肿瘤中观察到VCP/p97高表达。VCP/p97高表达与低PD-L1 TPS之间存在显著关联（p = 0.025），VCP/p97高表达与低iTILs之间也存在显著关联（p = 0.015）。VCP/p97与PD-L1 CPS之间未发现显著相关性。VCP/p97在OPSCC中未显示出预后意义。
展开英文摘要原文
VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC.
The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed.
High VCP/p97 expression was observed in 67.9% of the tumors. A significant association was found between high VCP/p97 expression and low PD-L1 TPS (p = 0.025) and between high VCP/p97 and low iTILs (p = 0.015). No significant correlation was found between VCP/p97 and PD-L1 CPS. VCP/p97 showed no prognostic significance in OPSCC.
VCP/p97 is frequently overexpressed in OPSCC. The significant association of high VCP/p97 expression with low PD-L1 TPS and reduced iTILs could indicate that VCP/p97 inhibitor therapy may enhance the efficacy of PD-1 checkpoint inhibitor therapy in OPSCC.
论文信息
- 作者
- Seuthe IMC、Ruwe M、Mitze F、Silling S、Ehrke-Schulz E、Eichhorn S、Park JJ
- 单位
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Witten/Herdecke, Catholic Hospital Hagen, Dreieckstraße 15, 58097, Germany, Hagen. inga.seuthe@uni-wh.de.Germany
- 期刊
- Discover oncology2025 Oct 20
- 原文标识
- PubMed 41114923 · DOI 10.1007/s12672-025-03839-8
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