CELL INTELLIGENCE · 肿瘤细胞治疗研究

CELLIN 肿瘤细胞治疗研究

← 返回

TPD52 促进胃癌细胞的增殖和转移

英文原题：TPD52 promotes the proliferation and metastasis of gastric cancer cells.

查看英文原题

TPD52 promotes the proliferation and metastasis of gastric cancer cells.

PubMed 2025/10/03（内容时间） BMC Gastroenterol Q2 · IF 3.2（JCR 2025）

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

技术：NK 细胞胃癌地区：中国
登录后收藏与关注 全文解读登录并开通会员后使用加入对比登录并开通会员后使用

中文摘要

免疫治疗改善了肿瘤患者的预后，但由于遗传和免疫抵抗，只有一小部分患者获益。提高其疗效至关重要。肿瘤蛋白 D52（TPD52）是一种新型免疫检查点，表达于 T 细胞、B 细胞和 NK 细胞，在免疫调节中发挥关键作用。

本研究旨在探讨 TPD52 在胃癌（GC）中的预后价值并探索其生物学功能。我们分析了 TCGA 和 GEO 数据集，以评估 TPD52 的转录表达、预后意义、免疫浸润及相关生物学功能。使用 CCK-8、集落形成和 transwell 实验研究 TPD52 在 GC 细胞中的生物学功能，同时使用实时定量 PCR 评估 GC 患者血清中 TPD52 的表达。ROC 分析评估了其对 GC 的诊断效能。

结果显示，TPD52 在大多数肿瘤和癌旁正常组织中表达失调，显著影响预后。TPD52 表达与免疫细胞浸润、肿瘤分子亚型和免疫检查点调控基因密切相关。GC 细胞系中 TPD52 表达升高促进细胞增殖、迁移和侵袭。

此外，GC 患者血清中 TPD52 水平较高，其与 CEA 和 CA199 联合增强了其对 GC 的诊断效能。总之，TPD52 影响免疫反应、免疫细胞浸润和肿瘤恶性程度，使其成为 GC 预后和免疫浸润的有前景的治疗靶点和生物标志物。

展开英文摘要原文

Immunotherapy has improved outcomes for tumor patients, but only a small proportion benefits due to genetic and immunological resistance. Enhancing its efficacy is crucial. Tumor protein D52 (TPD52), a novel immune checkpoint expressed in T cells, B cells, and NK cells, plays a key role in immune regulation. This research aimed to investigate the prognostic value of TPD52 in gastric cancer (GC) and explore its biological functions.

We analyzed the TCGA and GEO dataset to assess the transcriptional expression, prognostic significance, immune infiltration, and related biological functions of TPD52. Biological functions of TPD52 in GC cells were studied using CCK-8, colony formation, and transwell assays, while quantitative real-time PCR was used to assess TPD52 expression in the serum of GC patients.

ROC analysis evaluated its diagnostic efficiency for GC. Results showed that TPD52 was dysregulated in most tumors and adjacent normal tissues, significantly impacting prognosis. TPD52 expression was strongly correlated with immune cell infiltration, tumor molecular subtypes, and immune checkpoint-regulated genes. Elevated TPD52 expression in GC cell lines promoted cell proliferation, migration, and invasion.

Additionally, TPD52 levels were higher in the serum of GC patients, and their combination with CEA and CA199 enhanced its diagnostic efficiency for GC.

In conclusion, TPD52 influences immune responses, immune cell infiltration, and tumor malignancy, making it a promising therapeutic target and biomarker for GC prognosis and immune infiltration.

论文信息

作者
Zhang S、Geng Z、Sun J、Chen N、Liu M、Wang Y、Gu X、Pei B
第一作者单位
Department of Laboratory Medicine, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China.China
通讯作者单位
Department of Laboratory Medicine, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China. sqpeibing@njmu.edu.cn.China
期刊
BMC gastroenterology2025 Oct 3
原文标识
PubMed 41044492　·　DOI 10.1186/s12876-025-04295-y

在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →