肿瘤细胞治疗研究
英文原题：Strategies to Target the Tumor-Associated Macrophages in the Immunosuppressive Microenvironment of Pancreatic Ductal Adenocarcinoma.
Strategies to Target the Tumor-Associated Macrophages in the Immunosuppressive Microenvironment of Pancreatic Ductal Adenocarcinoma.
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胰腺导管腺癌（PDAC）是一种危重疾病，由于其全球发病率不断上升且相关生存率较低，亟需开发新的有效治疗方法。尽管包括免疫检查点抑制剂在内的免疫治疗已显示出对多种肿瘤的疗效，但为PDAC开发有效的治疗方法仍面临挑战。这主要归因于PDAC复杂而独特的免疫逃逸机制。近期研究揭示，肿瘤相关巨噬细胞（TAMs）在增强PDAC免疫逃逸中发挥关键作用。这种作用通过多种途径介导，包括细胞因子分泌以及对多种免疫细胞的激活或抑制。清晰理解巨噬细胞如何促进PDAC增殖，可能有助于开发针对TAMs的新型免疫治疗方法。在本综述中，我们总结了TAMs在PDAC中的多方面活动和作用，并探讨了免疫治疗方法对PDAC的潜在影响，特别关注嵌合抗原受体（CAR）巨噬细胞。本综述基于近期关于基于CAR巨噬细胞的实体瘤免疫治疗研究中有希望的发现。
Pancreatic ductal adenocarcinoma (PDAC) is a critical disease requiring the development of novel effective therapeutic approaches due to its increasing global incidence and associated low survival rates. While immunotherapy, including immune checkpoint inhibitors, has shown efficacy against various tumors, developing an effective treatment approach for PDAC poses a challenge. This is primarily attributed to the complex and distinctive immune evasion mechanisms of PDAC. Recent studies have revealed that tumor-associated macrophages (TAMs) play a crucial role in enhancing immune evasion in PDAC.
This role is mediated through multiple pathways, including cytokine secretion and the activation or suppression of diverse immune cells. A clear understanding of how macrophages contribute to PDAC proliferation could lead to the development of novel immune therapy approaches targeting TAMs.
In this review, we summarized the multifaceted activities and roles of TAMs in PDAC and explored the potential effect of immunotherapeutic approaches on PDAC, with a particular focus on chimeric antigen receptor (CAR) macrophages. This review was based on promising findings from recent studies on CAR macrophage-based immunotherapy for solid tumors.
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