CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Pancreatic Cancer Immunotherapy: A Team-Based Approach.
Pancreatic Cancer Immunotherapy: A Team-Based Approach.
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免疫治疗方法已在多种癌症中创建了有效且毒性可控的新型治疗手段，通常能带来更持久的缓解和疾病控制。在胰腺癌中，免疫治疗的疗效一直难以捕捉。已发现许多障碍导致免疫治疗在胰腺癌中疗效有限。恶劣的肿瘤微环境在胰腺癌免疫基础疗法的开发中起着重要作用。应对其中许多挑战的方法将需要团队协作，以优化我们对疾病、其微环境、各组分在胰腺癌发生和生长中的行为，以及用于最佳创建对胰腺癌患者具有持久疗效的疗法和治疗组合的机制的理解。
Immunotherapeutic approaches have created effective therapy with a manageable toxicity profile as a new treatment approach in a wide variety of cancers, often leading to longer responses and control of disease. In pancreatic cancer, responses to immunotherapy have been difficult to capture. Many obstacles have been identified in the limited efficacy of immunotherapy in pancreatic cancers. The hostile tumor microenvironment plays a large role in therapeutic development of immune-based therapies in pancreatic cancer.
The approach to addressing many of these challenges will require a team-based approach to optimize both our understanding of the disease, its microenvironment, and how each component behaves in the development and growth of pancreatic cancer as well as the mechanisms used to best create therapies and combinations of treatment that will have long-standing efficacy for pancreatic cancer patients.
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