γδ T 细胞调节小细胞肺癌中的抗肿瘤免疫
γδ T cells modulate anti-tumor immunity in small cell lung cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
人类心肌梗死和癌症中缺氧相关基因的鉴定
英文原题：Identification of Hypoxia-Related Genes in Human Myocardial Infarction and Cancers.
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Identification of Hypoxia-Related Genes in Human Myocardial Infarction and Cancers.
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研究概要
IER3、HMOX1、CDKN1A、PLAUR、MAFF、SLC2A3、JUN、TGFBI 和 PFKFB3 是 MI 和癌症的潜在生物标志物。对缺氧相关基因的研究可能为这两种疾病提供新的治疗靶点。
研究思路结论见上方概要
背景
心肌梗死（MI）和癌症合计占全球死亡率的50%以上。近期研究揭示了两者之间的多种关联，包括慢性炎症和氧化应激，尤其关注缺氧介导的信号通路。在缺血心肌中，缺氧触发细胞凋亡、纤维化和病理性组织重构；在肿瘤微环境（TME）中，缺氧驱动血管生成、代谢重编程和免疫逃逸。因此，识别MI中与缺氧相关的差异表达基因可能为MI和癌症的治疗提供新靶点。
方法
本研究中MI患者的标本取自Gene Expression Omnibus (GEO)数据库。利用R语言中的"limma"包和加权基因共表达网络分析(WGCNA)，筛选出一组缺氧相关差异表达基因。随后，对这些hub基因进行功能富集分析，并在独立数据集中验证其表达水平。最后，对hub基因进行转录调控分析和免疫浸润分析，并评估其在多种癌症中的表达水平及预后价值。
结果
在MI样本中，发现9个基因，即Immediate Early Response 3 (IER3)、Heme Oxygenase 1 (HMOX1)、Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A)、Plasminogen Activator Urokinase Receptor (PLAUR)、MAF BZIP Transcription Factor F (MAFF)、Solute Carrier Family 2 Member 3 (SLC2A3)、Jun Proto-Oncogene (JUN)、转化生长因子 Beta Induced (TGFBI)和6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)，表现出显著失调，并与多种癌症的发生密切相关。泛癌分析进一步揭示了hub基因与癌症预后的关联。免疫分析还揭示了它们与TME中静息CD4+记忆T细胞和gamma delta T细胞的关联。
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METHODS
The specimens from MI patients in this study were retrieved from the Gene Expression Omnibus (GEO) database. Using the "limma" package in R and weighted gene co-expression network analysis (WGCNA), a set of hypoxia-related differentially expressed genes was screened out. Subsequently, these hub genes were subjected to functional enrichment analysis, and their expression levels were verified in an independent dataset. Finally, transcriptional regulatory analysis and immune infiltration analysis were conducted for the hub genes, and their expression levels and prognostic values in various cancers were evaluated.
RESULTS
In MI samples, nine genes, namely Immediate Early Response 3 (IER3), Heme Oxygenase 1 (HMOX1), Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A), Plasminogen Activator Urokinase Receptor (PLAUR), MAF BZIP Transcription Factor F (MAFF), Solute Carrier Family 2 Member 3 (SLC2A3), Jun Proto-Oncogene (JUN), Transforming Growth Factor Beta Induced (TGFBI), and 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3), were found to demonstrate significant dysregulation and to be closely associated with the occurrence of various cancers. Pan-cancer analysis further revealed the association of hub genes with cancer prognosis. Immune analysis also revealed their associations with resting CD4+ memory T cells and gamma delta T cells in TME.
CONCLUSION
IER3, HMOX1, CDKN1A, PLAUR, MAFF, SLC2A3, JUN, TGFBI, and PFKFB3 are potential biomarkers for MI and cancer. Research on hypoxia-related genes may provide new therapeutic targets for these two diseases.
论文信息
- 作者
- Yan S、Fang Z、Xue X、Hou C、Yang X
- 单位
- Department of Cardiology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.China
- 期刊
- Cardiology2025 Aug 12
- 原文标识
- PubMed 40795764 · DOI 10.1159/000547896
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