CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Association of Tumor-Infiltrating Lymphocytes and Inflammation Status with Survival Outcome in Patients with High-Grade Serous Ovarian Carcinoma.
Association of Tumor-Infiltrating Lymphocytes and Inflammation Status with Survival Outcome in Patients with High-Grade Serous Ovarian Carcinoma.
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按照 TIL 工作组建议，通过人工评估和数字图像分析（DIA）评估 CD3 + /CD4 + /CD8 + /PD-1+ 间质性 TILs（sTILs）和上皮内 TILs（iTILs）。通过以下评分评估炎症状态：全身免疫炎症指数（SII）、泛免疫炎症值（PIV）、CA125 和乳酸脱氢酶（LDH）。
CD8 + TILs 是 iTILs 和 sTILs 中最常见的亚型。然而，除 PD-1+ 细胞外，在所有亚群中，sTILs 均显著多于 iTILs（p < 0.001）。TIL 评估的 DIA 结果与人工评估一致。高间质性 CD3 + 和 CD8 + TILs、PIV、CA125 和 LDH 与改善的 PFS 相关。人工评估中 PFS 的潜在独立预后因素为 PIV（HR = 0.32，CI 95% = 0.12-0.82）和 CD8 + sTILs（HR = 0.30，CI 95% = 0.12-0.79），而在 DIA 评估中为 CD3 + sTILs（HR = 0.31，CI 95% = 0.15-0.67）、PIV（HR = 0.35，95% CI 0.13-0.96）和残留病灶（HR = 0.21 95% CI 0.08-0.53）。
CD3 + /CD8 + sTILs 和 PIV 是 HGSC 中有前景的预后指标；然而，仍需进一步研究以确认其临床实用性。
Background/Objectives : Tumor-infiltrating lymphocytes (TILs) and inflammation status are emerging prognostic markers in various cancers, but their significance in high-grade serous ovarian carcinoma (HGSC) remains unclear.
Our objective was to evaluate different TIL subtypes and inflammation status in relation to progression-free survival (PFS) in primary HGSC. Methods : CD3 + /CD4 + /CD8 + /PD-1+ stromal TILs (sTILs) and intraepithelial TILs (iTILs) were evaluated by manual assessment and digital image analysis (DIA), following TIL Working Group recommendations.
Inflammation status was evaluated through the following scores: systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), CA125, and lactate dehydrogenase (LDH). Results : CD8 + TILs were the most prevalent subtype in both iTILs and sTILs.
However, sTILs were significantly more abundant than iTILs ( p < 0. 001) among all subsets, except for PD-1+ cells. DIA results of TIL assessments were in agreement with manual assessments. High stromal CD3 + and CD8 + TILs, PIV, CA125, and LDH, were associated with improved PFS. Potential independent prognostic factors for PFS in manual assessment were PIV (HR = 0. 32, CI 95% = 0. 12-0.
82) and CD8 + sTILs (HR = 0. 30, CI 95% = 0. 12-0. 79), whereas in DIA assessment they were CD3 + sTILs (HR = 0. 31, CI 95% = 0. 15-0. 67), PIV (HR = 0. 35, 95% CI 0. 13-0. 96), and residual disease (HR = 0. 21 95% CI 0. 08-0. 53). Conclusions : CD3 + /CD8 + sTILs and PIV are promising prognostic indicators in HGSC; however, further research is needed to confirm their clinical utility.
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