brexucabtagene autoleucel 治疗复发/难治性套细胞淋巴瘤的真实世界结局：一项 CIBMTR 分析

Brexucabtagene autoleucel (brexu-cel) is a chimeric antigen receptor T-cell therapy approved for relapsed/refractory mantle cell lymphoma (R/R MCL).

Here, we report real-world effectiveness and safety outcomes of brexu-cel in a prospective study of patients with R/R MCL, including subgroups based on prior treatment with Bruton's tyrosine kinase inhibitor, bendamustine, or autologous hematopoietic cell transplant (auto-HCT) and number of prior therapy lines, using Center for International Blood and Marrow Transplant Research registry data. A total of 476 patients with R/R MCL who received brexu-cel between July 2020 and December 2022 were included in the analysis. With a median follow-up of 13. 5 months, the overall response rate was 91% and complete response rate was 82%. One-year overall survival and progression-free survival rates were 76% and 63%, respectively. One-year cumulative incidence of nonrelapse mortality was 8%.

Prior auto-HCT was associated with better duration of response within 6 months after infusion (hazard ratio [HR], 0. 49; 95% confidence interval [CI], 0. 28-0. 85) but greater risk of immune effector cell-associated neurotoxicity syndrome (odds ratio [OR], 1. 66; 95% CI, 1. 06-2. 60). Prior bendamustine was associated with increased risk of prolonged thrombocytopenia (OR, 1.

90; 95% CI, 1. 13-3. 21). In patients with 1 to 2 prior therapy lines, relapse or progression was less frequent compared with those with ≥3 prior lines (HR, 0. 64; 95% CI, 0. 42-1. 00). Collectively, our results suggest that real-world outcomes with brexu-cel were consistent with those of the ZUMA-2 trial, regardless of prior therapy type or number of prior therapy lines.