CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞因子与免疫效应细胞治疗
英文原题：Cytokines and immune effector cell therapy.
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Cytokines and immune effector cell therapy.
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中文摘要
细胞因子在促进免疫效应细胞（IEC）疗法的疗效以及在与该疗法相关的独特毒性谱（包括CRS、ICANS和IEC-HS）的发生中均发挥不可或缺的作用。我们综述了在IEC生产过程中所使用的各种细胞因子，以及内源性细胞因子在细胞输注后促进成功扩增和活性方面的作用。我们讨论了重组外源性细胞因子在进一步促进T细胞活性方面的作用，以及被工程化改造为以自主方式表达信号传导细胞因子的下一代IEC产品。最后，我们讨论了若干IEC相关毒性的工作模型，重点强调细胞因子在驱动这些毒性中的关键作用，以及通过抗细胞因子疗法进行干预以克服这些毒性的策略。
展开英文摘要原文
Cytokines play an integral role in both promoting the efficacy of immune effector cell (IEC) therapies and in the development of the unique spectrum of associated toxicities, including CRS, ICANS, and IEC-HS.
We review the various cytokines that have been employed in the IEC manufacturing process as well as the role of endogenous cytokines in promoting successful expansion and activity following cell infusion.
We discuss the role of recombinant exogenous cytokines in further promoting T cell activity, as well as next-generation IEC products engineered to express cytokines that signal in an autonomous fashion.
Finally, we discuss working models of several IEC-associated toxicities, highlighting the crucial role of cytokines in driving these toxicities, as well as interventions with anti-cytokine therapies to overcome them.
论文信息
- 作者
- Haugh A、Frigault MJ
- 单位
- Massachusetts General Hospital, Boston, MA, USA. Electronic address: ahaugh@mgh.harvard.edu.United States
- 文献类型
- 综述
- 期刊
- Best practice & research. Clinical haematology2025 Jun
- 原文标识
- PubMed 40701742 · DOI 10.1016/j.beha.2025.101628