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良性肿瘤拓宽了免疫疗法的应用领域

英文原题:Benign tumors broaden the field of application for immunotherapy.

查看英文原题

Benign tumors broaden the field of application for immunotherapy.

PubMed 2025/06/24(内容时间) Front Immunol Q1 · IF 7(JCR 2025)

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中文摘要

免疫疗法在治疗恶性肿瘤方面已显示出巨大潜力。尚未被广泛考虑的是将免疫疗法用于治疗良性肿瘤的机会。通过聚焦于与特定良性肿瘤相关的特定遗传改变后所表达的可靶向抗原,免疫疗法可能为良性肿瘤治疗提供一种有效途径,从而避免更传统的手术需求。免疫疗法能够特异性识别并靶向肿瘤细胞,鉴于治疗可用的时间窗口较长,这对良性肿瘤尤其有益。因此,良性肿瘤因提供了更大的治疗机会窗口,且具有与有限突变负荷相关的相对稳定的表型,可以从针对每种病症独特相关抗原的免疫治疗策略中获得巨大益处。

展开英文摘要原文

Immunotherapy has shown significant potential for treating malignancies. Not yet widely considered is the opportunity to employ immunotherapy for the treatment of benign tumors.

By focusing on targetable antigens expressed following specific genetic changes associated with individual benign tumors, immunotherapy may provide an effective approach to benign tumor treatment, circumventing the need for more conventional surgery. Immunotherapies can specifically recognize and target tumor cells, which could be especially beneficial for benign tumors given the extended timeframe available for treatment.

Thus, benign tumors, offering a greater window of opportunity for treatment and a relatively stable phenotype associated with a limited mutation burden, can derive great benefit from immunotherapeutic approaches targeting antigens uniquely associated with each condition.

论文信息

作者
Youssef MA、Al-Sharif H、McGrath BT、Picken MM、Le Poole IC
第一作者单位
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.United States
通讯作者单位
Departments of Dermatology, Microbiology and Immunology, Robert H. Lurie Comprehensive Cancer Center, North Western University, Chicago, IL, United States.United States
文献类型
综述
期刊
Frontiers in immunology2025
原文标识
PubMed 40630962 · DOI 10.3389/fimmu.2025.1593960