CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
IL-18 可恢复功能失调的 CAR-T 细胞
英文原题：IL-18 revives dysfunctional CAR-T cells.
查看英文原题
IL-18 revives dysfunctional CAR-T cells.
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中文摘要
IL-18 装甲嵌合抗原受体（CAR）工程化 T（18.CAR-T）细胞在常规 CAR-T 治疗难治的淋巴瘤患者中已显示出增强的抗肿瘤疗效。揭示这种强效增强背后的机制并减轻相关毒性，可能开启一个具有更优疗效和更广泛临床影响的新一代 CAR-T 疗法的新时代。
展开英文摘要原文
IL-18-armored chimeric antigen receptor (CAR)-engineered T (18.CAR-T) cells have demonstrated enhanced antitumor efficacy in lymphoma patients refractory to conventional CAR-T therapy. Unraveling the mechanisms behind this potent enhancement and mitigating associated toxicities could unlock a new era of next-generation CAR-T therapies with superior effectiveness and broader clinical impact.
论文信息
- 作者
- Li YR、Zhu Y、Yang L
- 第一作者单位
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: charlie.li@ucla.edu.United States
- 通讯作者单位
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, Los Angeles, CA 90095, USA; Goodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: liliyang@ucla.edu.United States
- 期刊
- Trends in cancer2025 Oct
- 原文标识
- PubMed 40628538 · DOI 10.1016/j.trecan.2025.06.008