不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
循环肿瘤 DNA——从生物学到弥漫大 B 细胞淋巴瘤中的潜在临床应用
英文原题：Circulating tumor DNA - from biology to potential clinical applications in diffuse large B-cell lymphomas.
查看英文原题
Circulating tumor DNA - from biology to potential clinical applications in diffuse large B-cell lymphomas.
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中文摘要
在过去20年中，人们对癌细胞生物学的理解取得了显著进展。利用下一代测序技术对通过组织活检获取的肿瘤细胞进行分子谱评估，使得能够诊断特定的弥漫性大B细胞淋巴瘤亚型，并通过合理使用分子靶向药物来实现个体化治疗。与其他活检材料评估方法类似，该方法也存在一些局限性。当组织活检未能完全捕捉肿瘤内遗传异质性时，该方法可能会失败。因此，研究人员已着手寻找新的实验室方法，以研究癌细胞的遗传异质性，并一次性表征所有淋巴瘤细胞，而不论肿瘤细胞的来源及其转化阶段。一种有前景的诊断方法是利用分子生物学技术评估总游离循环DNA，包括循环肿瘤DNA。
展开英文摘要原文
During the last 20 years, significant progress has been made in understanding the biology of cancer cells. Assessment of the molecular profile of neoplastic cells collected by tissue biopsy using next-generation sequencing techniques makes it possible to diagnose the specific diffuse large B-cell lymphoma subtype and to personalize the therapy applied through the rational use of molecularly targeted drugs. Similar to the other methods of biopsy material evaluation, this method has some limitations.
It may fail in cases when tissue biopsies do not fully capture intratumor genetic heterogeneity. For this reason, research has been undertaken to find new laboratory methods to study the genetic heterogeneity of cancer cells and to characterize all lymphoma cells at once, regardless of the origin of the tumor cells and the stage of its transformation. One promising diagnostic approach is the evaluation of total free circulating DNA, including circulating tumor DNA, using molecular biology techniques.
论文信息
- 作者
- Lewandowski K、Gwóźdź-Bąk K
- 单位
- Department of Hematology and Bone Marrow Transplantation, University of Medical Science, Poznań, Poland.Poland
- 文献类型
- 综述
- 期刊
- Contemporary oncology (Poznan, Poland)2025
- 原文标识
- PubMed 40620893 · DOI 10.5114/wo.2025.150452
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