CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Beneficial effects of aerobic exercises on multiple myeloma: Mechanisms and clinical observations.
Beneficial effects of aerobic exercises on multiple myeloma: Mechanisms and clinical observations.
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关于多发性骨髓瘤（MM）——第二常见的血液系统恶性肿瘤——的研究，在运动对治疗作用方面显示出不确定的结果。本研究评估了体育锻炼与MM治疗结局之间的关系。在5T-MM小鼠模型中，荷瘤小鼠接受了包括硼替佐米和地塞米松在内的治疗，同时进行为期6周的低强度或中等强度跑台有氧训练。记录了肿瘤负荷和生存数据。
此外，对2013年至2024年在四川大学华西医院接受维持治疗的65例MM患者进行了回顾性分析。根据患者对世界卫生组织（WHO）身体活动指南的依从性进行分类，并分析了无进展生存期和维持治疗中的无进展生存期。在小鼠模型中，双药治疗与运动联合改善了结局，将生存期延长了10天以上。有氧运动减少了小鼠外周血中的调节性T细胞并增加了NK细胞。在运动组小鼠中，肌因子IL-15和鸢尾素上调，提示这两种肌因子均可能有助于抗MM免疫的调节。在患者研究中，符合WHO身体活动建议的患者表现出显著更好的无进展生存期（PFS）和维持治疗中的无进展生存期（PFSm）。
总体而言，适当的有氧运动可能使部分MM患者获益，提示运动作为MM治疗辅助手段的潜力。
Studies on multiple myeloma (MM), the second most common hematologic malignancy, have shown inconclusive results regarding the role of exercise in treatment.
This study evaluated the relationship between physical exercise and MM treatment outcomes. In the 5T-MM mouse model, tumor-bearing mice underwent treatment that included bortezomib and dexamethasone alongside 6 weeks of low- or moderate-intensity treadmill aerobic training. Tumor burden and survival data were recorded.
Additionally, a retrospective analysis was conducted on 65 MM patients undergoing maintenance therapy at West China Hospital from 2013 to 2024. Patients were categorized based on their adherence to the World Health Organization (WHO) physical activity guidelines, and progression-free survival and progression-free survival in maintenance therapy were analyzed. In the mouse model, the combination of dual-drug therapy and exercise improved outcomes, extending survival by more than 10 days.
Aerobic exercises reduced regulatory T cells and increased NK cells in the peripheral blood of mice. In the exercise group of mice, myokines IL-15 and irisin were up-regulated, implying both myokines could contribute to the regulation of anti-MM immunity. In the patient study, patients who met the WHO physical activity recommendations demonstrated significantly better progression-free survival (PFS) and progression-free survival in maintenance treatment (PFSm).
Overall, appropriate aerobic exercises may benefit some MM patients, suggesting a potential for exercise as an adjunct in MM treatment.
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