RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Effects of gastrointestinal motility therapy combined with acupuncture on gastrointestinal function in patients after laparoscopic radical surgery.
Effects of gastrointestinal motility therapy combined with acupuncture on gastrointestinal function in patients after laparoscopic radical surgery.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
胃肠动力治疗仪联合针刺促进胃癌根治术后胃肠功能恢复,调节胃肠激素和免疫功能,安全有效。
胃肠功能障碍在胃癌腹腔镜根治术后较为常见,并影响康复。虽然常规治疗可在一定程度上缓解症状,但往往无法完全解决胃肠动力不足的问题。胃肠动力治疗仪通过模拟胃肠电波促进动力恢复,而针刺则调节脏腑气机,两者均可提供有效干预。然而,探讨胃肠动力治疗与针刺联合使用以促进胃肠腹腔镜根治术后患者胃肠功能恢复的临床研究较少。
评估胃肠动力治疗仪联合针刺对腹腔镜根治术患者胃肠功能的影响。
本回顾性研究纳入2022年6月至2024年5月于同济大学医学院附属上海养志康复医院(上海市阳光康复中心)接受根治性GI内镜手术的196例患者。将患者分为常规组(常规治疗,n = 96)和综合组(常规+GI动力治疗仪+针刺,n = 100)。评估两组患者对GI功能、治疗前后激素水平、GI症状、免疫功能、不良反应及患者满意度的影响。
与正常组相比,综合组总体有效率显著更高(93.00% vs 84.3%;P < 0.05),首次排气、进食、排便及住院时间均更短(P < 0.05)。治疗后,综合组胃泌素及胃肠道症状评定量表评分更低,胃动素、血管活性肠肽及免疫标志物(CD3+、CD4+、CD4+/CD8+及NK 细胞)水平更高(P < 0.05)。与正常组相比,综合组不良反应更少(5.00% vs 14.58%),患者满意度更高(97.00% vs 84.38%),差异均有统计学意义(P < 0.05)。
Gastrointestinal (GI) dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation. While conventional treatments can alleviate symptoms to a certain extent, they often fail to fully address the issue of insufficient GI motility. The GI motility therapeutic apparatus promotes dynamic recovery by simulating GI electric waves, whereas acupuncture regulates zang-fu qi movement, both offering effective interventions. However, there are few clinical studies investigating the combined use of GI motility therapy and acupuncture to promote GI function recovery in patients after GI laparoscopic radical surgery. AIM: To evaluate the effects of combining GI motility therapy devices with acupuncture on GI function in patients undergoing radical laparoscopic surgery.
This retrospective study included 196 patients who underwent radical GI endoscopic surgery at the Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, from June 2022 to May 2024. Patients were classified into a normal group (conventional treatment, n = 96) and an integrated group (conventional + GI motility therapy device + acupuncture, n = 100). The effects on GI function, hormone levels pre- and post-treatment, GI symptoms, immune function, adverse reactions, and patient satisfaction in both groups were assessed.
Compared with the normal group, the integrated group demonstrated significantly better overall effectiveness (93.00% vs 84.3%; P < 0.05) and shorter durations for first exhaust, feeding, defecation, and hospital stay ( P < 0.05). Post-treatment, the integrated group had lower gastrin and GI symptom rating scale scores and higher motilin, vasoactive intestinal peptide, and immune marker (CD3+, CD4+, CD4+/CD8+, and natural killer cells) levels ( P < 0.05). The integrated group, compared to the normal group, also reported fewer adverse reactions (5.00% vs 14.58%) and higher patient satisfaction (97.00% vs 84.38%), both statistically significant ( P < 0.05).
The combination of a GI motility therapy device and acupuncture promotes GI function recovery after radical gastrectomy, regulates GI hormones and immune function, and is safe and effective.
在 PubMed 查看 → 出版商原文(DOI) 全文 PDF(PMC)· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
MEMBER ACCOUNT
登录成功会直接打开下一页。