CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤相关免疫细胞中的铁死亡：对抗肿瘤的双刃剑
英文原题：Ferroptosis in tumor associated immune cells: A double-edged sword against tumors.
查看英文原题
Ferroptosis in tumor associated immune cells: A double-edged sword against tumors.
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中文摘要
铁死亡是由于细胞内铁依赖性脂质过氧化积累而导致的调节性细胞死亡，为抗肿瘤治疗提供了潜在的新策略。近年来，越来越多的研究开始探索铁死亡与肿瘤微环境（TME）之间的相互作用，尤其是TME中免疫细胞与铁死亡的关系，揭示了铁死亡在肿瘤免疫治疗中的作用。本文总结了铁死亡的主要代谢途径和调控机制，并重点阐述了铁死亡在TME免疫细胞中的新作用，这可能为免疫治疗与铁死亡治疗的协同提供新的诊断、预后或治疗机会。
展开英文摘要原文
Ferroptosis is regulated cell death due to the accumulation of iron-dependent lipid peroxidation in cells, providing a potential new strategy for anti-tumor therapy. In recent years, more and more studies have begun to explore the interaction between ferroptosis and the tumor microenvironment (TME), especially the relationship between immune cells in the TME and ferroptosis, revealing the role of ferroptosis in tumor immunotherapy.
This article summarizes the main metabolic pathways and regulatory mechanisms of ferroptosis, and focuses on the new role of ferroptosis in immune cells in the TME, which may provide new diagnostic, prognostic or therapeutic opportunities for the cooperation of immunotherapy and ferroptosis treatment.
论文信息
- 作者
- Hu J、Cui L、Hou B、Ding X、Liu H、Sun W、Mi Y、Chen Y
- 第一作者单位
- MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China; Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.China
- 通讯作者单位
- MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China; Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China. Electronic address: zouzhengzhi@m.scnu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Critical reviews in oncology/hematology2025 Aug
- 原文标识
- PubMed 40570995 · DOI 10.1016/j.critrevonc.2025.104818