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泌尿生殖系统肿瘤基因组学与免疫治疗进展

英文原题:Advances in Genitourinary Tumor Genomics and Immunotherapy.

查看英文原题

Advances in Genitourinary Tumor Genomics and Immunotherapy.

PubMed 2025/05/30(内容时间) Genes (Basel) Q2 · IF 3.1(JCR 2025)

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中文摘要

免疫监测和调控技术的进步正在推动癌症免疫治疗的变革性变化。这些创新对于评估患者特异性免疫反应、更准确地预测治疗疗效以及改善治疗结果至关重要。本综述全面概述了当前用于免疫监测的技术,如流式细胞术、单细胞 RNA 测序和多重细胞因子分析。它还探讨了前沿的免疫调控方法,例如激活免疫细胞的生物材料和基因工程细胞疗法。我们审视了这些技术的优势和局限性,并确定了需要进一步进展的领域。特别是,我们探讨了个性化疗法、实时监测系统和人工智能如何塑造免疫治疗的未来。通过对现有平台和新兴解决方案的比较分析,本文强调了整合从免疫学和生物工程到数据科学等多种科学方法在推进更安全、更有效癌症治疗方面的重要性。这种跨学科方法有望提高免疫治疗的精准性和可及性,为改善癌症护理带来新的希望。

展开英文摘要原文

Advancements in immune monitoring and modulation technologies are driving transformative changes in cancer immunotherapy. These innovations are crucial for assessing patient-specific immune responses, enabling more accurate predictions of therapeutic efficacy and enhancing treatment outcomes.

This review provides a comprehensive overview of current technologies used in immune monitoring, such as flow cytometry, single-cell RNA sequencing, and multiplex cytokine profiling. It also explores cutting-edge immune modulation methods, such as biomaterials that activate immune cells and genetically engineered cell-based therapies.

We examine the strengths and limitations of these techniques and identify areas where further progress is needed. In particular, we explore how personalized therapies, real-time monitoring systems, and artificial intelligence shape the future of immune-based treatments.

Through a comparative analysis of existing platforms and emerging solutions, this paper underscores the importance of integrating diverse scientific approaches-from immunology and bioengineering to data science-in advancing safer, more effective cancer treatments. This interdisciplinary approach promises to enhance the precision and accessibility of immune-based therapies, offering new hope for improved cancer care.

论文信息

作者
Vohra J、Barbosa G、Pascoal LB、Reis LO
第一作者单位
Department of Biomedical Engineering, Vidyalankar Institute of Technology, Mumbai 400037, India.India
通讯作者单位
ImmuneOncology, Pontifical Catholic University of Campinas, PUC-Campinas, Campinas 13034-685, SP, Brazil.Brazil
文献类型
综述
期刊
Genes2025 May 30
原文标识
PubMed 40565559 · DOI 10.3390/genes16060667