← 返回

新兴化疗靶点:来自胶质瘤治疗进展的启示

英文原题:Emerging Chemotherapy Targets: Insights from Advances in Glioma Treatment.

查看英文原题

Emerging Chemotherapy Targets: Insights from Advances in Glioma Treatment.

PubMed 2025/06/12(内容时间) Biomedicines Q2 · IF 4.5(JCR 2025)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

原发性脑肿瘤是当代研究的重要焦点。随着技术的进步以及通过新型诊断方法对病例检出率的提高,创新疗法和化疗方法不断涌现。本文探讨了胶质母细胞瘤化疗的最新进展,重点介绍了提供有价值机制见解的创新方法。文章深入探讨了胶质瘤新兴疗法的作用机制、分子靶点及未来潜力。此外,本文还概述了一系列疗法的研究,包括各种化疗药物、CAR-T 细胞疗法、靶向细胞呼吸的药物以及其他方法。同时,本文还讨论了化疗相关的挑战,包括血脑屏障、耐药性和免疫抑制,并提出了克服这些障碍的潜在解决方案。

展开英文摘要原文

Primary brain tumors represent a significant focus of contemporary research. With advancements in technology and the increasing detection of cases through novel diagnostic methods, innovative therapies and approaches to chemotherapy continue to emerge. The paper explores recent advancements in chemotherapy for glioblastoma, highlighting innovative approaches that provide valuable mechanistic insights. It delves into the mechanisms of action, molecular targets, and the future potential of emerging therapies for gliomas.

Additionally, this paper offers an overview investigating a range of therapies, including various chemotherapeutic agents, CAR-T cell therapies, drugs targeting cellular respiration, and other approaches.

Furthermore, the paper addresses chemotherapy-related challenges, including the blood-brain barrier, drug resistance, and immunosuppression, while proposing potential solutions to overcome these obstacles.

论文信息

作者
Rezk R、Hanna AG、Hutchinson H、Farag M、Lucke-Wold B
第一作者单位
College of Medicine, University of Florida, Gainesville, FL 32610, USA.United States
通讯作者单位
Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.United States
文献类型
综述
期刊
Biomedicines2025 Jun 12
原文标识
PubMed 40564171 · DOI 10.3390/biomedicines13061452