CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Advances in cancer immunotherapy: The role of super NK and super CAR-T cells.
Advances in cancer immunotherapy: The role of super NK and super CAR-T cells.
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免疫治疗在最近一段时间已确立为治疗多种癌症中更有前景的策略之一。在已描述的疗法中,最有效的是自然杀伤(NK)细胞和CAR-T(CAR-T)细胞,且已知二者在杀伤癌细胞方面相当有效。近来为开发这些免疫细胞而进行的此类干预已增强其益处,并包括超级 NK 和超级 CAR-T 细胞。两类细胞疗法均利用机体免疫,以较传统方法实现更优越的肿瘤杀伤机制。在这个意义上,超级 NK 细胞提供了一种现货型、同种异体解决方案,可最大限度减少早期免疫学不良反应,而超级 CAR-T 细胞的结果更具个性化,在血液系统癌症疾病中具有令人印象深刻的应答。然而,已注意到某些关键并发症,包括细胞因子释放综合征和神经毒性,这需要更多研究和创新。本综述旨在考虑这些疗法的可能性,更确切地说,讨论此类疗法的作用、其功能、类型以及关于癌症免疫治疗的发展。
Immunotherapy has over the recent past established itself as one of the more promising strategies in the treatment of several cancers. Among the described ones, the most efficient are natural killer (NK) cells and chimeric antigen receptor T (CAR-T) cells and both of them are known to be rather effective in killing the cancer cells. Such interventions recently attempted to develop these immune cells have enhanced its beneficence and includes super NK and super CAR-T cells. Cell therapies both types employ the body immunity in order to achieve a superior Tumour killing mechanism over conventional approaches.
In this sense, super NK cells provide an out-of-shelf, allogeneic solution that would minimize the early immunological adverse reactions, compared to super CAR-T cells where the outcome is more personalized, with impressive responses in hematological cancer diseases.
Nevertheless, certain critical complications, including cytokine release syndrome and neurotoxicity have been noted which require more study and innovation. This review aims at considering the possibilities of these therapies, more precisely, speaking about the roles of such therapies, their functions, types and concerning the development of cancer immunotherapy.
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