CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
病例报告：累及弥漫大 B 细胞淋巴瘤 (DLBCL) 和脑膜瘤的碰撞瘤
英文原题：Case Report: Collision Tumor Involving Diffuse Large B-Cell Lymphoma (DLBCL) and Meningioma.
查看英文原题
Case Report: Collision Tumor Involving Diffuse Large B-Cell Lymphoma (DLBCL) and Meningioma.
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中文摘要
我们报告一名73岁男性病例。患者最初诊断为睾丸IE期弥漫性大B细胞淋巴瘤（DLBCL），MRI偶然发现右额部轴外肿块，影像特征符合凸面脑膜瘤。DLBCL治疗后不足2年复发，出现多处淋巴瘤病灶，且18F-FDG PET-CT显示增大的轴外脑膜肿块摄取增加。CD19 CAR-T 治疗后，除额部肿块外均达到完全代谢缓解。手术切除发现该病灶为DLBCL与脑膜上皮型脑膜瘤构成的碰撞瘤。碰撞瘤是指两种组织学不同的肿瘤占据同一解剖部位，较为少见，发生于中枢神经系统者尤其罕见。
展开英文摘要原文
We report on a 73-year-old man, initially diagnosed with testicular stage IE DLBCL and an incidental finding of an extra-axial right frontal mass with MRI features of a convexity meningioma. The DLCBL relapsed <2 years after treatment, with multiple lymphoma localizations and increased uptake in the grown extra-axial meningeal mass on 18 F-FDG PET-CT.
CD19-CAR-T therapy induced a complete metabolic response with the exception of the frontal mass. Surgical resection revealed a collision tumor involving DLBCL and meningothelial meningioma. Collision tumors-2 histologically different neoplasms that occupy the same anatomic location-are uncommon, especially those occurring in the central nervous system.
论文信息
- 作者
- Lippens J、Cordier F、Daneels W、Genbrugge E、Van den Broeck B、Van Weehaeghe D
- 第一作者单位
- Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.Belgium
- 通讯作者单位
- Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.Belgium
- 文献类型
- 病例报告
- 期刊
- Clinical nuclear medicine2025 Oct 1
- 原文标识
- PubMed 40474366 · DOI 10.1097/RLU.0000000000005775