不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
结外鼻型 NK/T 细胞淋巴瘤治疗：一项多中心研究的分析
英文原题：Extranodal Nasal-Type NK/T-Cell Lymphoma Treatment: Analysis from a Multicenter Study.
查看英文原题
Extranodal Nasal-Type NK/T-Cell Lymphoma Treatment: Analysis from a Multicenter Study.
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研究概要
ENKL 患者的预后已通过使用不含蒽环类药物的治疗方案得到改善，但晚期患者的死亡率仍然很高。
研究思路结论见上方概要
背景
结外自然杀伤/T细胞淋巴瘤，鼻型（ENKL），或称鼻NK/T细胞淋巴瘤，是被称为“致死性中线肉芽肿”综合征的最常见病因。
目的
在本研究中，我们旨在分析结外自然杀伤（NK）/T细胞淋巴瘤的治疗结果。
方法
对来自15个中心的39例患者的数据进行了回顾性评估。观察了决定患者风险状态的特征、他们接受的治疗以及他们的反应。
结果
21例（53.8%）接受一线治疗的患者达到完全缓解。中位随访时间为12.5个月（范围，1-60个月），高进展期疾病患者的死亡率为56.4%。中位总生存期为16个月（95% CI，13.07-18.93）。
展开英文摘要原文
BACKGROUND
Extranodal natural killer/T-cell lymphoma, nasal type (ENKL), or nasal NK/T-cell lymphoma is the most common cause of the syndrome known as "fatal midline granuloma." AIM: In this study, we aimed to analyze the treatment outcomes of extranodal natural killer (NK)/T-cell lymphomas.
METHODS
Data of 39 patients from 15 centers were evaluated retrospectively. The characteristics that determine the risk status of the patients, in which treatments they received, and their responses were observed.
RESULTS
Complete response was achieved in 21 patients (53.8%) who received first-line therapy. Median follow-up was 12.5 months (range, 1-60 months) and mortality was 56.4% in patients with highly advanced disease. Median overall survival was 16 (95% CI, 13.07-18.93) months.
CONCLUSION
The prognosis of patients with ENKL has been improved with the use of anthracycline-free treatments, but mortality rates remain high in advanced patients.
论文信息
- 作者
- Sahin D、Soyer N、Yeral M、Namdaroglu S、Hindilerden F、Aydogdu I、Ozturk H、Turgut B
- 第一作者单位
- Department of Hematology, Etlik City Hospital, Ankara, Turkey.Turkey
- 通讯作者单位
- Department of Hematology and Apheresis Unit, University of Health Sciences, Ankara Oncology Training and Research Hospital, Ankara, Turkey.Turkey
- 文献类型
- 多中心研究
- 期刊
- Nigerian journal of clinical practice2025 May 1
- 原文标识
- PubMed 40462333 · DOI 10.4103/njcp.njcp_499_24