间皮素作为癌症免疫治疗的生物标志物和治疗靶点
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.
癌症仍是一个关键的全球健康问题，原因在于发现晚、耐药和高死亡率。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
幽门螺杆菌与胃癌中较少的 TIL（肿瘤浸润淋巴细胞）和不良预后相关
英文原题：Helicobacter pylori is associated with less tumor-infiltrating lymphocytes and a poor prognosis in gastric cancer.
查看英文原题
Helicobacter pylori is associated with less tumor-infiltrating lymphocytes and a poor prognosis in gastric cancer.
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研究概要
我们的研究支持这一假说：H。
中文摘要
背景
幽门螺杆菌（H. pylori）具有致癌性，可导致胃黏膜病变进展及胃癌（GC）；它也是胃癌肿瘤微环境（TME）的重要组成部分。TME中TIL（肿瘤浸润淋巴细胞）的浸润和功能状态会影响机体抗肿瘤功能。然而，H. pylori对胃癌抗肿瘤免疫及预后的影响尚不清楚。
方法
本研究构建组织芯片，纳入H. pylori感染和未感染患者的胃癌组织。分别采用苏木精-伊红（H&E）染色和免疫组织化学（IHC）染色评估TIL状态以及CD3、CD8和PD-L1表达，并开展相关性、Cox回归及生存分析。
结果
TIL、CD3和CD8与H. pylori感染呈负相关。此外，TIL水平高及CD8⁺ TIL状态与较好生存结局正相关。同时，H. pylori阳性患者的生存情况较阴性组差。
结论
本研究支持以下假设：H. pylori感染与较少的TIL和CD8⁺ TIL相关，这可能促成抗肿瘤免疫逃逸，进而导致胃癌预后较差。
展开英文摘要原文
BACKGROUND
Helicobacter pylori (H. pylori) is carcinogenic and has the potential to cause progressive gastric lesions and gastric cancer (GC), which also represents one of the essential constituents of the tumor microenvironment (TME) of GC. The infiltration and functional status of tumor-infiltrating lymphocytes (TILs) in the TME affect the anti-tumor function of the body. However, the impact of H. pylori on anti-tumor immunity and prognosis of GC is still unclear.
METHODS
In this study, we constructed a tissue microarray (TMA) consisting of GC tissues from patients with or without H. pylori infection. We evaluated the status of TILs and the expression of CD3, CD8 and PD-L1 by Hematoxylin-eosin (H&E) staining and immunohistochemical (IHC) staining, respectively. Correlation, Cox regression, and survival analyses were performed.
RESULTS
We found that TIL, CD3, and CD8 were negatively correlated with H. pylori infection. In addition, TIL high and CD8 + TILs status were positively associated with better survival. Simultaneously, patients with H. pylori-positive status had decreased survival compared to those in the H. pylori-negative group.
CONCLUSIONS
Our study supports the hypothesis that H. pylori infection was positively correlated with less TILs and CD8 + TILs, which may contribute to anti-tumor immune escape, thus lead to a poor prognosis of GC.
论文信息
- 作者
- Chen Z、Zhang Z、Huang H、Lu C、Li Q、Yan M、Zhu C、Wang S
- 第一作者单位
- Gastric Cancer Center, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, P. R. China.China
- 通讯作者单位
- Gastric Cancer Center, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, P. R. China. soslizheng@njmu.edu.cn.China
- 期刊
- BMC gastroenterology2025 May 30
- 原文标识
- PubMed 40448000 · DOI 10.1186/s12876-025-04003-w
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