CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Mechanisms underlying resistance to CAR-T cell therapy and strategies for enhancement.
Mechanisms underlying resistance to CAR-T cell therapy and strategies for enhancement.
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嵌合抗原受体（CAR）T细胞疗法已成为治疗血液系统恶性肿瘤的革命性方法，包括急性淋巴细胞白血病、B细胞淋巴瘤和多发性骨髓瘤。尽管前景良好，但疗效常难以持久，随后发生的复发限制了治疗的长期成功。当前研究聚焦于通过探索多靶点策略和优化CAR-T 细胞设计来克服这些障碍。本综述总结CAR-T 细胞疗法相关耐药机制的最新认识，并阐述优化CAR构建体的新兴策略，包括多抗原靶向、改良CAR设计和增强T细胞持久性。本文旨在全面概述该领域现状，为未来研究和CAR-T 细胞疗法的临床应用提供指导。
Chimeric antigen receptor (CAR) T-cell therapy has emerged as a revolutionary approach in the treatment of hematological malignancies, including acute lymphoblastic leukemia, B-cell lymphoma, and multiple myeloma. Despite its promise, the clinical efficacy is often hampered by transient efficacy and subsequent relapse, which curtail the long-term success of this treatment. Current research focuses on overcoming these obstacles by exploring multitarget strategies and optimizing CAR-T cell design.
This review summarizes recent insights into the resistance mechanisms associated with CAR-T cell therapy, and delineates emerging strategies for optimized CAR construction, including targeting multiple antigens, improving CAR design, and enhancing T-cell persistence. The goal is to provide a comprehensive overview of the field's current landscape to guide future research and the clinical application of CAR-T cell therapies.
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