组织驻留记忆 T 细胞在肿瘤发生和癌症免疫治疗中的多方面功能

Tissue-resident memory T (T RM ) cells are well reported as a strong protective first line of defense against foreign antigens in non-lymphoid tissues.

Moreover, T RM cells have demonstrated critical protective roles in antitumor immunity, contributing to enhanced survival and tumor growth inhibition across various cancer types.

However, surprisingly, recent studies suggest that T RM cells can exhibit paradoxical effects, potentially promoting tumor progression under certain conditions and leading to adverse outcomes during antitumor immune responses. Understanding the complexities of T RM cell functions will enable us to harness their potential in advancing cancer immunotherapy more effectively.

Therefore, this review comprehensively investigates the dual roles of T RM cells in different tumor contexts, highlighting their protective functions in combating cancers and their unfavorable potential to exacerbate tumor development.

Additionally, we explore the implications of T RM cell behaviors for future cancer treatment strategies, emphasizing the need for further research to optimize the therapeutic exploitation of T RM cells while mitigating their deleterious effects.