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TIL(肿瘤浸润淋巴细胞)免疫治疗走向成熟:NCI 外科部的发展历程

英文原题:Tumor-infiltrating lymphocyte immunotherapy comes of age: a journey of development in the Surgery Branch, NCI.

查看英文原题

Tumor-infiltrating lymphocyte immunotherapy comes of age: a journey of development in the Surgery Branch, NCI.

PubMed 2025/04/09(内容时间) J Immunother Cancer Q1 · IF 11.7(JCR 2025)

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中文摘要

TIL(肿瘤浸润淋巴细胞)发展为有效临床策略,最初主要归功于美国国家癌症研究所外科分部数百名科学家和临床医生在Steven Rosenberg领导下的工作。这一历程加深了人们对肿瘤与免疫细胞界面的认识,并最终帮助为转移性癌症患者开发出一种首创疗法。

展开英文摘要原文

The early development of tumor-infiltrating lymphocytes into an effective clinical strategy was fundamentally the work of hundreds of scientists and clinicians within the Surgery Branch of the National Cancer Institute under the leadership of Steven Rosenberg. That journey brought new insights into the tumor-immune cell interface and ultimately helped create a new first-in-class therapeutic for patients with metastatic cancer.

论文信息

作者
Goff SL、Rosenberg SA
单位
Surgery Branch, National Cancer Institute Center for Cancer Research, Bethesda, Maryland, USA stephanie.goff@nih.gov.United States
文献类型
历史回顾
期刊
Journal for immunotherapy of cancer2025 Apr 9
原文标识
PubMed 40210239 · DOI 10.1136/jitc-2025-011734