CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:A Bibliometric Analysis of Immunotherapy in Diffuse Large B-Cell Lymphoma from 2004 to 2024.
A Bibliometric Analysis of Immunotherapy in Diffuse Large B-Cell Lymphoma from 2004 to 2024.
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这是首项全面总结弥漫大 B 细胞淋巴瘤免疫治疗研究趋势与进展的文献计量学研究。
检索 Web of Science 核心合集数据库中 2004 至 2024 年与 DLBCL 免疫治疗相关的论文和综述。使用 VOSviewer、CiteSpace 及 R 软件包“bibliometrix”开展文献计量分析。
共纳入 662 篇论文。DLBCL 免疫治疗相关研究数量逐年增加。论文来自 55 个国家,以美国和中国为首;涉及 1,349 家机构,其中领先研究机构为德克萨斯大学 MD 安德森癌症中心和纪念斯隆凯特琳癌症中心。Leukemia & Lymphoma 是发文量最多的期刊,Blood 是共被引最多的期刊。共识别 4,833 位作者,其中 Young 和 Ken H. 发表的重要论文最多,Neelapu S.S. 的共被引数量最多。分析发现最常见的关键词为 CAR-T(CAR-T 细胞,即CAR-T 细胞免疫疗法;这是当前仍在发展的研究领域)。
这是首项全面总结 DLBCL 免疫治疗研究趋势与进展的文献计量研究。通过明确 CAR-T 细胞、双特异性抗体等近期研究前沿和热点,这些信息可为免疫治疗研究人员及医疗服务提供者提供参考。
The Web of Science Core Collection database was searched for articles and reviews related to the immunotherapy of DLBCL from 2004 to 2024. VOSviewers, CiteSpace, and the R package "bibliometrix" were used to conduct the bibliometric analysis.
A total of 662 articles were included. The number of immunotherapy treatments in DLBCL increased year by year. The publications came from 55 countries, led by the USA and the People's Republic of China, and 1,349 institutions, with the leading research institutions being The University of Texas MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center. Leukemia & Lymphoma is the journal with the most research, and Blood is the journal with the most co-citations. We identified 4,833 authors, among which Young and Ken H. had the most significant articles, while Neelapu S.S. had the largest number of co-citations. After analysis, the most common keyword is CAR T (CAR T cells: chimeric antigen receptor T-cell immunotherapy, a current and developing area of research.
This is the first bibliometric study to comprehensively summarize research trends and advances in immunotherapy in DLBCL disease. This information will provide a reference for researchers and healthcare providers in immunotherapy research by clarifying recent research frontiers and hot spots such as CAR T cells, bispecific antibodies, and so on.
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