CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞外囊泡在肿瘤免疫治疗中的前景
英文原题：Prospect of extracellular vesicles in tumor immunotherapy.
查看英文原题
Prospect of extracellular vesicles in tumor immunotherapy.
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中文摘要
细胞外囊泡（EVs）作为细胞来源的小囊泡，通过运输生物分子促进肿瘤微环境（TME）中的细胞间通讯。不同来源的EVs内容物各异，表现出促进或抑制癌症进展的差异化功能。因此，调控EVs的形成、分泌和摄取成为癌症干预的新策略。EV分离技术的进步激发了人们对基于EV的疗法的兴趣，尤其是在肿瘤免疫治疗方面。本综述探讨了不同来源的EVs在肿瘤免疫治疗中的多方面功能，重点介绍了它们在癌症疫苗和过继性细胞治疗中的潜力。此外，我们探索了EVs作为纳米颗粒递送系统在肿瘤免疫治疗中的潜力。最后，我们讨论了EVs在临床环境中的现状和未来方向，旨在提供关键信息以推进EVs在癌症治疗中的开发和临床应用。
展开英文摘要原文
Extracellular vesicles (EVs), as cell-derived small vesicles, facilitate intercellular communication within the tumor microenvironment (TME) by transporting biomolecules. EVs from different sources have varied contents, demonstrating differentiated functions that can either promote or inhibit cancer progression.
Thus, regulating the formation, secretion, and intake of EVs becomes a new strategy for cancer intervention. Advancements in EV isolation techniques have spurred interest in EV-based therapies, particularly for tumor immunotherapy. This review explores the multifaceted functions of EVs from various sources in tumor immunotherapy, highlighting their potential in cancer vaccines and adoptive cell therapy.
Furthermore, we explore the potential of EVs as nanoparticle delivery systems in tumor immunotherapy.
Finally, we discuss the current state of EVs in clinical settings and future directions, aiming to provide crucial information to advance the development and clinical application of EVs for cancer treatment.
论文信息
- 作者
- Xia W、Tan Y、Liu Y、Xie N、Zhu H
- 单位
- Department of Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, China.China
- 文献类型
- 综述
- 期刊
- Frontiers in immunology2025
- 原文标识
- PubMed 40078996 · DOI 10.3389/fimmu.2025.1525052
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