CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
联合自体造血干细胞移植与 CD19 CAR-T 细胞治疗伴 TP53 突变的复发/难治性弥漫大 B 细胞淋巴瘤：病例报告
英文原题：Combined autologous hematopoietic stem cell transplantation and CD19 CAR T-cell therapy for relapsed/refractory diffuse large B-cell lymphoma with TP53 mutation: A case report.
查看英文原题
Combined autologous hematopoietic stem cell transplantation and CD19 CAR T-cell therapy for relapsed/refractory diffuse large B-cell lymphoma with TP53 mutation: A case report.
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中文摘要
尽管弥漫性大B细胞淋巴瘤的治疗取得了进展，包括CAR-T 细胞疗法，但TP53突变仍是复发/难治性弥漫性大B细胞淋巴瘤患者重要的不良预后因素。自体干细胞移植与CAR-T 细胞疗法的联合可能改善长期预后并减少不良反应，包括严重的细胞因子释放综合征。本病例报告介绍了一名41岁男性复发/难治性弥漫性大B细胞淋巴瘤患者，携带TP53突变，接受了自体干细胞移植联合CD19 CAR-T 细胞治疗。治疗后两年，患者持续完全缓解，凸显了该联合方案对携带TP53突变的复发/难治性弥漫性大B细胞淋巴瘤的潜在疗效。
展开英文摘要原文
Despite advancements in the treatment of diffuse large B-cell lymphoma, including CAR T-cell therapy, TP53 mutations remain a significant negative prognostic factor in patients with relapsed/refractory diffuse large B-cell lymphoma. The combination of autologous stem cell transplantation and CAR T-cell therapy may enhance long-term prognosis and reduce adverse effects, including severe cytokine release syndrome.
This case report presents a 41-year-old man with relapsed/refractory diffuse large B-cell lymphoma harboring TP53 mutations who underwent autologous stem cell transplantation combined with CD19 CAR T-cell therapy. Two years posttreatment, the patient remains in sustained complete remission, highlighting the potential efficacy of this combination approach for relapsed/refractory diffuse large B-cell lymphoma with TP53 mutation.
论文信息
- 作者
- Cai Z、Zou D、Ma Q、Sun W、Guo Y
- 单位
- Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, P. R. China.China
- 文献类型
- 病例报告
- 期刊
- SAGE open medical case reports2025
- 原文标识
- PubMed 40078172 · DOI 10.1177/2050313X241306236
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