RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
骨髓免疫细胞与急性髓系白血病耐药性
英文原题：Bone marrow immune cells and drug resistance in acute myeloid leukemia.
查看英文原题
Bone marrow immune cells and drug resistance in acute myeloid leukemia.
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中文摘要
近年来，骨髓免疫抑制微环境与急性髓系白血病（AML）治疗抵抗的关系成为研究热点。免疫抑制细胞数量和功能异常，包括调节性T细胞（Tregs）和髓源性抑制细胞（MDSCs），以及免疫效应细胞功能障碍和耗竭，包括细胞毒性T淋巴细胞（CTLs）、树突状细胞（DCs）和NK 细胞（NKs），可诱导白血病细胞免疫逃逸，与白血病治疗抵抗密切相关。本文就骨髓微环境中免疫细胞与AML化疗耐药关系的研究进展进行综述，旨在为AML的免疫治疗提供新思路。
展开英文摘要原文
In recent years, the relationship between the immunosuppressive niche of the bone marrow and therapy resistance in acute myeloid leukemia (AML) has become a research focus. The abnormal number and function of immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), along with the dysfunction and exhaustion of immunological effector cells, including cytotoxic T lymphocytes (CTLs), dendritic cells (DCs) and natural killer cells (NKs), can induce immune escape of leukemia cells and are closely linked to therapy resistance in leukemia.
This article reviews the research progress on the relationship between immune cells in the marrow microenvironment and chemoresistance in AML, aiming to provide new ideas for the immunotherapy of AML.
论文信息
- 作者
- Zhang M、Yang Y、Liu J、Guo L、Guo Q、Liu W
- 单位
- Department of Pediatrics (Hematological Oncology), Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.China
- 文献类型
- 综述
- 期刊
- Experimental biology and medicine (Maywood, N.J.)2025
- 原文标识
- PubMed 40008144 · DOI 10.3389/ebm.2025.10235
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