肿瘤细胞治疗研究
英文原题：Targeting YTHDF2 impacts the epitranscriptome and overcomes tumor therapy resistance.
RNA 修饰因子的失调在各类癌症中普遍存在，并在肿瘤治疗耐药中发挥关键作用。
RNA 修饰因子失调常见于多种癌症，并在肿瘤治疗耐药中发挥重要作用。Chen 及其同事报告，YTHDF2 在 B 细胞恶性肿瘤中具有双重作用：促进细胞增殖并推动免疫逃逸。通过抑制剂靶向 YTHDF2、调节表观转录组，为肿瘤治疗提供了一种策略。
Dysregulation of RNA modifiers is common across cancer types and has essential roles in tumor therapy resistance. Chen and colleagues reported that YTHDF2 played dual roles in B cell malignancies by enhancing cell proliferation and promoting immune evasion. Targeting YTHDF2 with inhibitors offers an approach to tumor treatment by regulating the epitranscriptome.
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