CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
B 细胞淋巴瘤淋巴结 CAR-T 细胞治疗的数学模型
英文原题：Mathematical Model of CAR T-Cell Therapy for a B-Cell Lymphoma Lymph Node.
查看英文原题
Mathematical Model of CAR T-Cell Therapy for a B-Cell Lymphoma Lymph Node.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
CAR-T 细胞疗法在治疗儿童和年轻成人的B细胞白血病方面已展现出显著的成功。然而，与白血病相比，其在治疗B细胞淋巴瘤方面的有效性一直有限。在本文中，我们提出了一个数学模型，阐明了淋巴结中弥漫性大B细胞淋巴瘤和CAR-T 细胞的动力学。该数学模型有助于理解所涉及细胞群体之间复杂的相互作用，并提出识别治疗失败潜在动力学原因的方法。我们还研究了肿瘤细胞诱导的免疫抑制现象，并从理论上证明了其对细胞动力学的影响。通过考察各种应答情景，我们强调了产品特性在治疗结果中的重要性。
展开英文摘要原文
CAR T-cell therapies have demonstrated significant success in treating B-cell leukemia in children and young adults.
However, their effectiveness in treating B-cell lymphomas has been limited in comparison to leukemia. In this paper we present a mathematical model that elucidates the dynamics of diffuse large B-cell lymphoma and CAR T-cells in a lymph node. The mathematical model aids in understanding the complex interplay between the cell populations involved and proposes ways to identify potential underlying dynamical causes of treatment failure.
We also study the phenomenon of immunosuppression induced by tumor cells and theoretically demonstrate its impact on cell dynamics. Through the examination of various response scenarios, we underscore the significance of product characteristics in treatment outcomes.
论文信息
- 作者
- Sabir S、León-Triana O、Serrano S、Barrio R、Pérez-García VM
- 单位
- Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain. Soukaina.Sabir@uclm.es.Spain
- 期刊
- Bulletin of mathematical biology2025 Feb 7
- 原文标识
- PubMed 39918662 · DOI 10.1007/s11538-025-01417-1
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →