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Brexucabtagene Autoleucel 对比异基因造血细胞移植治疗复发/难治性套细胞淋巴瘤

英文原题:Brexucabtagene Autoleucel versus Allogeneic Hematopoietic Cell Transplantation in Relapsed and Refractory Mantle Cell Lymphoma.

查看英文原题

Brexucabtagene Autoleucel versus Allogeneic Hematopoietic Cell Transplantation in Relapsed and Refractory Mantle Cell Lymphoma.

PubMed 2025/05/05(内容时间) Blood Cancer Discov Q1 · IF 12.2(JCR 2025)

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中文摘要

年龄≥50岁的r/r MCL患者接受brexu-cel治疗后,与alloHCT相比,1年OS更优且非复发死亡率更低。然而,两种治疗的长期PFS和OS相似。个体化风险-获益评估对于指导最佳治疗决策至关重要。

展开英文摘要原文

Patients aged ≥50 years with r/r MCL had superior OS and lower nonrelapse mortality 1 year after receiving brexu-cel compared with alloHCT. However, the long-term PFS and OS are similar for both treatments. Individual risk-benefit evaluation is essential to guide optimal treatment decisions.

论文信息

作者
Liebers N、Boumendil A、Finel H、Edelmann D、Kobbe G、Baermann BN、Serroukh Y、Blaise D
单位
Department of Hematology, Oncology and Clinical Immunology, University Hospital Duesseldorf, Duesseldorf, Germany.Germany
期刊
Blood cancer discovery2025 May 5
原文标识
PubMed 39913291 · DOI 10.1158/2643-3230.BCD-24-0178