不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
伴嗜酸性粒细胞增多的头颈部经典型霍奇金淋巴瘤、T 细胞和 NK 细胞淋巴瘤
英文原题：Head and Neck Classic Hodgkin, T and NK Lymphomas with Eosinophilia.
查看英文原题
Head and Neck Classic Hodgkin, T and NK Lymphomas with Eosinophilia.
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中文摘要
嗜酸性粒细胞增多是多种血液系统恶性肿瘤的显著特征，包括可能发生于头颈部的特定类型白血病和淋巴瘤。在血液系统恶性肿瘤中，嗜酸性粒细胞增多可以是原发性的，由遗传异常驱动，也可以是继发性的，由肿瘤细胞或肿瘤微环境产生细胞因子和趋化因子所致。本综述探讨了嗜酸性粒细胞增多与头颈部血液淋巴系统恶性肿瘤之间的关联，包括经典型霍奇金淋巴瘤、T细胞淋巴母细胞白血病、成熟T细胞和NK细胞淋巴瘤以及朗格汉斯细胞组织细胞增生症。本文探讨了这些恶性肿瘤中嗜酸性粒细胞增多的潜在机制，重点阐述了IL-5、TARC和eotaxin等趋化因子和细胞因子的作用。识别嗜酸性粒细胞增多可能有助于这些疾病的诊断，而理解嗜酸性粒细胞增多的机制可能为潜在的预后意义和治疗策略提供见解。
展开英文摘要原文
Eosinophilia is a notable feature in various hematological malignancies, including specific types of leukemias and lymphomas that may occur in the head and neck. In hematologic malignancies, eosinophilia can be primary, driven by genetic abnormalities, or secondary, resulting from cytokine and chemokine production by the neoplastic cells or the tumor microenvironment.
This review examines the association between eosinophilia and head and neck hematolymphoid malignancies including Classic Hodgkin lymphoma, T-cell lymphoblastic leukemia, mature T and NK-cell lymphomas, and Langerhans cell histiocytosis.
It explores the underlying mechanisms of eosinophilia in these malignancies, highlighting the role of chemokines and cytokines such as IL-5, TARC, and eotaxin. Recognition of eosinophilia may aid in the diagnosis of these conditions and understanding the mechanisms of eosinophilia may provide insights into potential prognostic implications and treatment strategies.
论文信息
- 作者
- Danielson DT、Aguilera NS、Auerbach A
- 单位
- Department of Pathology, Walter Reed National Military Medical Center, Bethesda, MD, USA. David.t.danielson.mil@health.mil.United States
- 文献类型
- 综述
- 期刊
- Head and neck pathology2025 Jan 28
- 原文标识
- PubMed 39873807 · DOI 10.1007/s12105-025-01751-9
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