CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
Claudins 作为诊断工具和治疗靶点——地平线一瞥
英文原题：Claudins as diagnostic tools and therapeutic targets-Glimpse of the horizon.
查看英文原题
Claudins as diagnostic tools and therapeutic targets-Glimpse of the horizon.
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中文摘要
Claudins（CLDNs）作为紧密连接结构中不可或缺的基本组成部分，发挥着至关重要且不可替代的作用。由于CLDNs在正常组织和恶性肿瘤组织中表现出独特而特异的分布模式，这些蛋白作为系统性抗肿瘤治疗的关键靶点以及值得关注的诊断标志物，已引起广泛关注。本综述全面而详细地阐述了围绕CLDNs的基本认识、其复杂的表达模式、在癌症诊断中可能发挥的作用及治疗潜力；所有这些内容均以对前沿进展和来自各项临床试验信息的简要总结形式加以概括。
展开英文摘要原文
Claudins (CLDNs) play a crucial and indispensable role as fundamental components within the structure of tight junctions. Due to the distinct and unique distribution pattern exhibited by CLDNs in both normal and malignant tissues, these proteins have garnered significant attention as pivotal targets for systemic anti-cancer therapy and as noteworthy diagnostic markers.
This review provides a comprehensive and detailed elucidation of the fundamental understanding surrounding CLDNs, their intricate expression patterns, the potential role they play in cancer diagnosis and therapeutic potentials; all encapsulated within a succinct summary of the cutting-edge advancements and the information derived from various clinical trials.
论文信息
- 作者
- Sugiyama K、Chau I
- 第一作者单位
- Gastrointestinal Unit, Department of Medicine, Royal Marsden Hospital, London and Surrey, UK; Department of Medical Oncology, NHO Nagoya Medical Center, Nagoya, Aichi, Japan.United Kingdom
- 通讯作者单位
- Gastrointestinal Unit, Department of Medicine, Royal Marsden Hospital, London and Surrey, UK. Electronic address: ian.chau@rmh.nhs.uk.United Kingdom
- 文献类型
- 综述
- 期刊
- Cancer treatment reviews2025 Feb
- 原文标识
- PubMed 39847825 · DOI 10.1016/j.ctrv.2025.102888