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接受 CAR-T 细胞治疗患者的未满足需求与生活体验

英文原题:Unmet needs and lived experience of patients receiving CAR T-cell therapy.

查看英文原题

Unmet needs and lived experience of patients receiving CAR T-cell therapy.

PubMed 2025/01/21(内容时间) Leuk Lymphoma Q3 · IF 2.1(JCR 2025)

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中文摘要

CAR-T 细胞疗法是治疗血液系统恶性肿瘤的有效疗法和前景广阔的前沿方向。然而,这一革命性治疗也给患者、照护者和医疗系统带来了新的挑战。在这篇综述文章中,我们讨论患者在CAR-T 输注后急性和长期阶段面临的各种困难。我们重点介绍应对这些困难的各种方式,以及为改善患者体验所需进一步开展的研究和支持领域。此外,我们还考虑照护者和医疗系统所承受的困难和负担,以及获得CAR-T 治疗的障碍。最后,我们讨论未来研究和干预开发的方向,以满足患者和照护者的需求并改善公平可及性。我们提出,将专科姑息治疗早期整合到接受CAR-T 治疗的患者及其照护者中,是一项有前景的策略,有助于改善患者体验并满足其需求。

展开英文摘要原文

Chimeric Antigen Receptor T-Cell (CAR-T) therapy is an effective therapy and promising frontier in the treatment of hematologic malignancies.

However, this revolutionary treatment has led to new challenges for patients, caregivers, and the healthcare system. In this review article, we discuss the various difficulties patients face both in the acute and long-term period following CAR-T infusion.

We highlight the various ways these difficulties are addressed, as well as further areas of research and support needed to improve patient experience.

Additionally, we consider the difficulties and burdens placed on caregivers and healthcare systems, as well as barriers to accessing CAR-T therapy.

Finally, we address future directions of research and intervention development to meet patient and caregiver needs and improve equitable access.

We pose early integration of specialty palliative care for individuals and their caregivers undergoing CAR-T therapy as one promising strategy to help improve patient experience and meet their needs.

论文信息

作者
O'Shea PJ、Johnson PC、El-Jawahri A、Leblanc TW
单位
Department of Medicine, Duke University School of Medicine, Durham, NC, USA.United States
文献类型
综述
期刊
Leukemia & lymphoma2025 Jun
原文标识
PubMed 39838695 · DOI 10.1080/10428194.2025.2455488