← 返回

口腔癌预防和治疗策略的进展:一篇简短综述

英文原题:Advances in Preventive and Therapeutic Strategies for Oral Cancer: A Short Review.

查看英文原题

Advances in Preventive and Therapeutic Strategies for Oral Cancer: A Short Review.

PubMed 2024/12/30(内容时间) J Cancer Prev Q3 · IF 2.5(JCR 2025)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

口腔癌是一个全球性的重大健康问题,具有高发病率和死亡率,尤其是在高危人群中。早期诊断仍然是一个挑战,目前的治疗方法,如手术、放疗和化疗,效果有限,特别是在晚期阶段。靶向治疗和免疫治疗的最新进展提供了有前景的替代方案,提供了更精确和个性化的治疗选择。靶向治疗,如表皮生长因子受体抑制剂,旨在破坏肿瘤生长中的特定分子通路,而免疫治疗,包括免疫检查点抑制剂和CAR-T 细胞疗法,增强身体的免疫反应以对抗癌症。联合治疗,整合靶向和免疫策略,正在被探索以克服单药治疗的局限性。本综述重点介绍了口腔癌预防和治疗的当前策略,讨论了新兴疗法,探索了未来的研究方向,重点关注优化现有治疗、识别新的生物标志物和开发创新治疗方法。个性化医疗和联合治疗的潜力为改善口腔癌患者的生存率和生活质量带来了新的希望。

展开英文摘要原文

Oral cancer is a major global health concern, with high incidence and mortality rates, especially in high-risk populations. Early diagnosis remains a challenge, and current treatments, such as surgery, radiation, and chemotherapy, have limited effectiveness, particularly in advanced stages. Recent advances in targeted therapies and immunotherapy offer promising alternatives, providing more precise and personalized treatment options. Targeted therapies, such as epidermal growth factor receptor inhibitors, aim to disrupt specific molecular pathways in tumor growth, while immunotherapies, including immune checkpoint inhibitors and chimeric antigen receptor-T cell therapy, enhance the body's immune response to fight cancer.

Combination therapies, integrating both targeted and immune strategies, are being explored to overcome the limitations of single-agent treatments. This review highlights the current strategies in the prevention and treatment of oral cancer, discusses emerging therapies, explores future research directions, focusing on optimizing existing treatments, identifying new biomarkers, and developing innovative therapeutic approaches.

The potential of personalized medicine and combination therapies offers new hope for improving survival rates and quality of life for oral cancer patients.

论文信息

作者
Ma L、Kim MO
单位
Department of Animal Science and Biotechnology, Research Institute for Innovative Animal Science, Kyungpook National University, Sangju, Korea.South Korea
文献类型
综述
期刊
Journal of cancer prevention2024 Dec 30
原文标识
PubMed 39790224 · DOI 10.15430/JCP.24.027