CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
血液系统恶性肿瘤中的嵌合抗原受体治疗
英文原题：Chimeric antigen receptor therapy in hematologic malignancies.
查看英文原题
Chimeric antigen receptor therapy in hematologic malignancies.
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中文摘要
CAR-T 细胞疗法已显著推动白血病、淋巴瘤和多发性骨髓瘤等血液系统癌症的治疗，目前在实体瘤中也显示出希望。这类免疫疗法可使血液系统恶性肿瘤患者获得较高缓解率，但可能引发严重不良反应，包括细胞因子释放综合征和免疫效应细胞相关神经毒性综合征。本文介绍CAR-T 细胞疗法，为照护接受该疗法患者的基层医疗人员提供指导，并指出仍需开展研究以提高CAR-T 治疗的安全性和疗效。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy has led to significant advances in the treatment of blood cancers such as leukemia, lymphoma, and multiple myeloma, and now shows promise for solid tumors. This type of immunotherapy can achieve high response rates in patients with hematologic malignancies, but carries serious adverse reactions, including cytokine release syndrome and immune-effector cell-associated neurotoxicity syndrome.
This article describes CAR T-cell therapy, guidance for primary care providers caring for patients undergoing therapy, and the ongoing need for research to enhance CAR T-cell therapy's safety and effectiveness.
论文信息
- 作者
- Brownlee E、Turley M、Nations H
- 第一作者单位
- In the PA program at the University of Florida in Gainesville, Fla., Elizabeth Brownlee is director of didactic education and Melissa Turley is interim program director and a clinical assistant professor. Heather Nations practices in obstetrics and gynecology at UF Health Physicians in Gainesville. The authors have disclosed no potential conflicts of interest, financial or otherwise.
- 文献类型
- 综述
- 期刊
- JAAPA : official journal of the American Academy of Physician Assistants2025 Feb 1
- 原文标识
- PubMed 39761467 · DOI 10.1097/01.JAA.0000000000000176