CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
脂质通过塑造 T 细胞的代谢和功能适应性来引导其抗肿瘤免疫
英文原题：Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness.
查看英文原题
Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness.
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中文摘要
脂质是代谢信使，对能量产生、膜结构和信号转导至关重要。除了已知的作用外，脂质已成为T细胞反应的代谢调节器，不同种类的脂质以不同方式调节CD8+ T细胞（CTL）的命运和功能。事实上，脂质可以通过改变膜组成来影响T细胞信号传导；此外，它们还可以通过细胞代谢影响T细胞的分化路径。本综述讨论了脂质塑造T细胞表型和功能的能力。基于脂质代谢、代谢适应性与免疫监视之间的这种联系，我们提出脂质可以合理地整合到免疫治疗中，以精细调节过继性T细胞治疗（ACT）产品的适应性和功能。
展开英文摘要原文
Lipids are metabolic messengers essential for energy production, membrane structure, and signal transduction. Beyond their recognized role, lipids have emerged as metabolic rheostats of T cell responses, with distinct species differentially modulating CD8+ T cell (CTL) fate and function. Indeed, lipids can influence T cell signaling by altering their membrane composition; in addition, they can affect the differentiation path of T cells through cellular metabolism.
This Review discusses the ability of lipids to shape T cell phenotypes and functions. Based on this link between lipid metabolism, metabolic fitness and immunosurveillance, we suggest that lipid could be rationally integrated in the context of immunotherapies to fine-tune fitness and function of adoptive T cell therapy (ACT) products.
论文信息
- 作者
- Rumiano L、Manzo T
- 第一作者单位
- Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.Italy
- 通讯作者单位
- Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy. Electronic address: teresa.manzo@unito.it.Italy
- 文献类型
- 综述
- 期刊
- Trends in endocrinology and metabolism: TEM2025 Sep
- 原文标识
- PubMed 39743401 · DOI 10.1016/j.tem.2024.11.014