肿瘤细胞治疗研究
英文原题：Role of exosomes in modulating non-small cell lung cancer radiosensitivity.
非小细胞肺癌（NSCLC）在肺癌病例中占相当大的比例，尽管治疗方式不断进步，放疗耐药仍是有效癌症管理中的重大障碍。
非小细胞肺癌（NSCLC）占肺癌病例的很大比例。尽管治疗方式不断进步，放射治疗耐药仍是有效控制癌症的一大障碍。外泌体是细胞分泌的小囊泡，已成为细胞间通讯的重要参与者，可影响多种生物过程，包括癌症进展和治疗应答。本文综述外泌体调节NSCLC放射敏感性的复杂作用，重点介绍肿瘤来源外泌体如何通过增强DNA修复、调节免疫应答和改变肿瘤微环境促进放射耐受。文章还探讨间充质干细胞来源外泌体克服放疗耐药的潜力，以及其作为预测治疗结局生物标志物的可能性。理解外泌体影响放疗的机制，可为提高疗效和改善NSCLC患者生存率开辟新途径。
Non-small cell lung cancer (NSCLC) constitutes a significant proportion of lung cancer cases, and despite advancements in treatment modalities, radiotherapy resistance remains a substantial hurdle in effective cancer management. Exosomes, which are small vesicles secreted by cells, have emerged as pivotal players in intercellular communication and influence various biological processes, including cancer progression and the response to therapy. This review discusses the intricate role of exosomes in the modulation of NSCLC radiosensitivity. The paper focuses on NSCLC and highlights how tumor-derived exosomes contribute to radioresistance by enhancing DNA repair, modulating immune responses, and altering the tumor microenvironment. We further explore the potential of mesenchymal stem cell-derived exosomes to overcome radiotherapy resistance and their potential as biomarkers for predicting therapeutic outcomes. Understanding the mechanisms by which exosomes affect radiotherapy can provide new avenues for enhancing treatment efficacy and improving the survival rates of patients with NSCLC.
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